II. Definitions

  1. Phagocyte (and Phagosome, Phagocytosis)
    1. Immune cells (Neutrophils and Monocytes/Macrophages) are White Blood Cells that engulf pathogens and foreign material
    2. Phagosomes are the membrane engulfed pathogens
    3. Often combined with lysis by Lysozymes
  2. Lysosome (and Lysozyme)
    1. Lysozyme-containing vacuoles produced in cellular golgi apparatus
    2. Lysomsomes fuse with Phagosomes, resulting in pathogen lysis (esp. Bacterial cell walls)
    3. Lysosomes, like Phagosomes, are found in Phagocytes (Macrophages and Neutrophils)
  3. Opsonin (and Opsonization)
    1. Proteins (e.g. Antibody, complement, C-Reactive Protein) that bind a pathogen surface, targeting it for Phagocytosis

III. Epidemiology

  1. Phagocytic Disorders account for 8.5% of U.S. and 12.5% of European Primary Immunodeficiency cases

IV. Physiology

  1. See Also Immune System
  2. Phagocytes (Neutrophils and Macrophages) are critical to clearing infections
    1. Phagocytosis.jpg
  3. Phagosomes (Phagocytosis)
    1. Phagocytes such as Neutrophils (PMNs) and Macrophages attract and engulf organisms (Phagocytosis)
    2. Phagocytes attract organisms which in turn activate Phagocytosis
    3. Phagosomes are later lysed via Lysosomes (as below)
  4. Lysosomes
    1. Neutrophil's and Macrophage's (Phagocytes) golgi apparatus produce Lysosomes (vacuoles) that contain Lysozyme
    2. Lysosomes fuse with Phagosomes to produce phagolysosomes, degrading the engulfed organisms
    3. Lysosomes may also release their contents extracellularly to lyse larger targets too large to engulf

V. Complications

  1. Disorders of Neutrophils or Monocytes/Macrophages
  2. Fungal Lung Infections
  3. Recurrent abscesses or delayed Wound Healing
  4. May present with invasive infections
  5. Catalase positive infections (consider especially if invasive infections)
    1. Staphylococcus aureus
    2. Pseudomonas
    3. Aspergillus
    4. Burkholderia cepacia
    5. Nocardia
    6. Serratia
    7. Candida

VI. Causes: Neutropenia - Decreased Absolute Neutrophil Count (ANC<500/ul)

  1. See Neutropenia
  2. Chemotherapy-related Neutropenia
  3. Severe Congenital Neutropenia
    1. Presents in first few weeks of life
    2. Omphalitis
  4. Autoimmune Neutropenia
  5. Cyclic Neutropenia
    1. Neutrophil numbers fluctuate in 21 day cycle

VII. Causes: Decreased Neutrophil Function

  1. Chronic Granulomatous Disease (CGD)
    1. Inherited Phagocyte NADPH oxidase abnormality
      1. Phagocyte oxidase converts oxygen to Reactive Oxygen Intermediates (ROI)
      2. Without ROIs (e.g. superoxide anions), Phagocytes can not lyse and destroy engulfed microbes
      3. Results in defect of PMN intracellular killing
    2. Typically diagnosed by age 5 years old
    3. May first present as omphalitis in infants
    4. Recurrent in Intracellular Bacterial and fungal infections, abscesses and Granulomas
      1. Examples: Pneumonia, abscesses, suppurative adenitis, gastrointestinal infections
  2. Leukocyte Adhesion Deficiency (type 1)
    1. Adhesion molecules allow Phagocytes to adhere to vascular endothelium and migrate to infection site
    2. Leukocyte adhesion deficiency presents in first few weeks of life
      1. Delayed Umbilical Cord separation beyond 4 weeks after birth
      2. Omphalitis
    3. Other findings
      1. Poor Wound Healing
      2. Erosive perianal ulcers
      3. Severe Bacterial Infections (e.g. Pneumonia, chronic Skin Infections)
  3. Chediak-Higashi Syndrome
    1. Rare Autosomal Recessive disorder affecting intracellular Protein transport
    2. Immunodeficiency
      1. Neutropenia
      2. Neutrophil Dysfunction (defective chemotaxis and bactericidal activity)
      3. Natural Killer Cell dysfuncton
    3. Presentations
      1. Severe infections (often fatal in childhood)
      2. Lymphoma-like presentations
      3. Partial oculocutaneous albinism
      4. Hepatosplenomegaly
      5. Lymphadenopathy
      6. Blood count abnormalities
        1. Anemia
        2. Platelets deficient in dense bodies (results in Bleeding Disorder)

VIII. Resources

  1. National Primary Immunodeficiency Resource Center
    1. http://npi.jmfworld.org
  2. Immune Deficiency Foundation
    1. http://www.primaryimmune.org

Images: Related links to external sites (from Bing)

Related Studies

Ontology: Chediak-Higashi Syndrome (C0007965)

Definition (NCI) A rare autosomal recessive immunodeficiency disorder characterized by abnormal intracellular protein transport. Chediak-Higashi syndrome (CHS) is characterized by immune deficiency; partial oculocutaneous albinism; a bleeding disorder due to deficient platelet dense bodies; neutropenia; neutrophils with impaired chemotaxis and bactericidal activity; recurrent infection; and abnormal natural killer (NK) cell function. CHS may be associated with hepatosplenomegaly, lymphadenopathy, anemia, thrombocytopenia, roentgenologic changes in bones, lungs and heart, and skin and psychomotor abnormalities; it is often fatal in childhood as a result of infection or an accelerated lymphoma-like phase. CHS occurs in mink, cattle, and mice, as well as man.
Definition (MSH) A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.
Definition (CSP) form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections; in many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions; transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.
Concepts Disease or Syndrome (T047)
MSH D002609
ICD10 E70.330 , D72.0
SnomedCT 123309000, 111396008, 191356000, 190696004
English Chediak Higashi Syndrome, Syndrome, Chediak-Higashi, Chediak Higashi syndrome, Chediak-Steinbrinck-Higashi sy, CHEDIAK-HIGASHI SYNDROME, CHS, Chediak Higashi anomaly, hereditary leukomelanopathy, Chediak-Higashi disease, Chediak-Higashi disease (diagnosis), hereditary leukomelanopathy (diagnosis), Chediak-Higashi disease (oculocutaneous albinism), Begnez Cesar disease, Chediak-Higashi syndrome, Chediak-Higashi Syndrome [Disease/Finding], Chediak-Higashi Syndrome, chediak higashi anomaly, chediak higashi syndrome, chediak-higashi syndrome, Oculocutaneous Albinism with Leukocyte Defect, Chediak-Steinbrinck-Higashi Syndrome, Chediak - Steinbrinck anomaly, Chediak-Higashi syndrome (disorder), Beguez Cesar disease, Chediak anomaly, Chediak-Steinbrinck anomaly, Congenital gigantism of peroxidase granules, Granulation anomaly of leukocytes, Hereditary gigantism of cytoplasmic organelles, Hereditary leukomelanopathy, Steinbrinck anomaly, Chediak-Steinbrinck-Higashi syndrome, Béguez César disease, Chédiak anomaly, Chédiak-Higashi syndrome (disorder), Chédiak-Higashi syndrome, Chédiak-Steinbrinck anomaly, Granulation anomaly of leucocytes, leukomelanopathy; hereditary, Chediak-Higashi; anomaly, Chediak-Higashi, anomaly; Chediak-Higashi, Chediak-Higashi syndrome -RETIRED-, Granulation anomaly or syndrome, Chediak-Steinbrinck-Higashi, Granulation anomaly or syndrome, Chediak-Steinbrinck, Granulocyte anomaly or syndrome, Chediak-Steinbrinck-Higashi, Granulocyte anomaly or syndrome, Chediak-Steinbrinck, Anomaly or syndrome, Chediak-Steinbrinck-Higashi, Anomaly or syndrome, Chediak-Steinbrinck
Dutch ziekte van Begnez Cezar, Chediak-Higashi; anomalie, anomalie; Chediak-Higashi, leukomelanopathie; hereditair, syndroom van Chediak-Higashi, Chediak-Higashi-syndroom, Syndroom, Chediak-Higashi-
French Maladie de Chediak-Steinbrinck-Higashi, Syndrome de Chediak-Steinbrinck-Higashi, Syndrome de Chediak-Higashi
German Begnez Cesar-Syndrom, Chediak-Higashi Syndrom, Chediak-Higashi-Syndrom, Chediak-Steinbrinck-Higashi-Syndrom
Italian Malattia di Begnez Cesar, Sindrome di Chediak-Higashi
Portuguese Doença de Begnez Cesar, Síndrome de Chediak-Higashi
Spanish Enfermedad de Begnez Cesars, síndrome de Chediak - Higashi - RETIRADO -, síndrome de Chediak - Higashi - RETIRADO - (concepto no activo), anomalía de Chédiak - Steinbrink, anomalía de Chédiak, anomalía de Steinbrinck, anomalía de las granulaciones de los leucocitos, enfermedad de Béguez César, gigantismo congénito de los gránulos de peroxidasa, gigantismo hereditario de organelas citoplasmáticas, leucomelanopatía hereditaria, síndrome de Chediak-Steinbrinck-Higashi, síndrome de Chédiak - Higashi (trastorno), síndrome de Chédiak - Higashi, Síndrome de Chediak-Higashi
Japanese ベグネ・セザール病, チェディアック・東症候群, ベグネセザールビョウ, チェディアックヒガシショウコウグン
Swedish Chediak-Higashis syndrom
Czech Chediakův-Higashiho syndrom, Syndrom Chediak-Higashi, Chédiakův-Higashiho syndrom
Finnish Chédiak-Higashin oireyhtymä
Polish Zespół Chediaka-Higashiego
Hungarian Begnez cesar betegség, Chediak-Higashi syndroma
Norwegian Chediak-Higashis sykdom, Chediak-Steinbrinck-Higashis syndrom

Ontology: Functional disorders of polymorphonuclear neutrophils (C0016808)

Concepts Disease or Syndrome (T047)
ICD9 288.1
ICD10 D71
SnomedCT 191351005, 267543009
Dutch functionele stoornissen van polymorfnucleaire neutrofielen, functionele stoornissen van neutrofiele polymorfnucleaire cellen, Functionele stoornissen van polymorfonucleaire neutrofielen
French Troubles fonctionnels des neutrophiles polymorphonucléaires, Troubles fonctionnels des polymorphonucléaires neutrophiles
German Funktionsstoerungen polymorphkerniger Neutrophile, Funktionsstoerungen neutrophiler Polymorphkerniger, Funktionelle Stoerungen der neutrophilen Granulozyten
Italian Disturbi funzionali dei polimorfonucleati neutrofili
Portuguese Perturbações funcionais dos neutrófilos polimorfonucleares
Spanish Trastornos funcionales de los polimorfonucleares neutrófilos, Trastornos funcionales de los neutrófilos polimorfonucleares, trastornos funcionales de neutrófilos polimorfonucleares (trastorno), trastornos funcionales de neutrófilos polimorfonucleares
English Polymorph.neutrophil funct.dis, Functional disorders of neutrophil polymorphonuclears, Function dis neutrophils, functional disorder of polymorphonuclear neutrophils, functional disorder of polymorphonuclear neutrophils (diagnosis), Functional disorders of polymorphonuclear neutrophils, Functional disorders of polymorphonuclear neutrophils (disorder)
Czech Poruchy funkce neutrofilních polymorfonukleárů
Korean 다형핵 호중구의 기능적 장애
Hungarian polymorphonuclearis neutrophilek functionális elváltozásai, neutrophil [polymorphonuclearis] funkcionális betegsége

Ontology: Chronic granulomatous disease (C0018203)

Definition (MSH) A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.
Definition (NCI) A rare genetic disorder with a predominantly X-linked recessive pattern of inheritance resulting in impaired phagocytic clearance of bacteria and fungi. It is caused by a defect in the phagocytic NADPH oxidase (phox) complex. The phagocytes can engulf pathogens but are unable to produce the microbicidal precursors needed to destroy them. Clinical signs of severe disease present in childhood with milder forms later in life. They include recurrent infection especially pneumonia, cervical lymphadenopathy and hepatosplenomegaly. The clinical course includes the appearance of granulomata in the skin and gastrointestinal or genitourinary tracts. The clinical prognosis is dependent on effectively treating and preventing infection.
Definition (CSP) recessive X-linked defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation.
Concepts Disease or Syndrome (T047)
MSH D006105
ICD10 D71
SnomedCT 11210002, 191354002, 387759001, 191352003
English Chronic Granulomatous Diseases, Disease, Chronic Granulomatous, Diseases, Chronic Granulomatous, Granulomatous Disease, Chronic, Granulomatous Diseases, Chronic, CGD - Chronic granulomat dis, GRANULOMATOUS DIS CHRONIC, chronic granulomatous disease, chronic granulomatous disease (diagnosis), Granulomatous Disease, Chronic [Disease/Finding], granulomatous chronic disease, cgd, chronic disease granulomatous, Chronic granulomatous disease, Chronic Granulomatous Disease, congenital dysphagocytosis (diagnosis), CGD - Chronic granulomatous disease, Congenital dysphagocytosis, Chronic granulomatous disease (disorder), Congenital dysphagocytosis (disorder), dysphagocytosis; congenital, Chronic granulomatous disease, NOS, CGD
French MGC, Maladie granulomateuse chronique, Granulomatose chronique, GSC (Granulomatose Septique Chronique), Granulomatose septique chronique, Maladie granulomateuse chronique infantile
German CGD, chronische Granulomatose, Granulomatose, chronische
Spanish EGC, disfagocitosis congénita (trastorno), disfagocitosis congénita, enfermedad granulomatosa crónica (trastorno), enfermedad granulomatosa crónica, Enfermedad granulomatosa crónica, Enfermedad Granulomatosa Crónica
Japanese 慢性肉芽腫性疾患, マンセイニクゲシュセイシッカン
Swedish Granulomatös sjukdom, kronisk
Czech granulomatózní nemoc chronická, CGD - chronická granulomatóza, Chronické granulomatózní onemocnění
Finnish Krooninen granulomatoosi
Polish Ziarnica septyczna przewlekła, Choroba ziarniniakowa przewlekła
Hungarian Chronikus granulomás betegség, CGD
Norwegian Kronisk granulomatøs sykdom, Kronisk granulomatose
Dutch dysfagocytose; congenitaal, chronische granulomateuze ziekte, Chronische granulomateuze ziekte, Chronische granulomatose, Granulomatose, chronische
Portuguese Doença granulomatosa crónica, Doença Granulomatosa Crônica
Italian Malattia granulomatosa cronica

Ontology: Lysosomes (C0024369)

Definition (GO) A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
Definition (NCI) A class of morphologically heterogeneous cytoplasmic membrane-bound vesicle in animal and plant tissues characterized by their content of a wide variety of glycoprotein hydrolytic enzymes active at an acid pH and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells and is supposed to be under metabolic (hormonal) control.
Definition (NCI_NCI-GLOSS) A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed.
Definition (MSH) A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Definition (CSP) morphologically heterogeneous cytoplasmic particles characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes, normally involved in the process of localized intracellular digestion; the activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured.
Concepts Cell Component (T026)
MSH D008247
SnomedCT 52971004
LNC LP71706-3
English Lysosome, Lysosoma, lysosome, lysosomes, lysosoma, Lysosomes, Lysosome (cell structure), Lysosome, NOS, Lysosome (body structure)
French Lysosome, Lysosomes
Swedish Lysosomer
Czech lyzozómy, lyzosomy
Finnish Lysosomit
Italian Lisosoma, Lisosomi
Latvian Not Translated[Lysosomes]
Polish Lizosomy
Japanese リソソーム, ライソソーム, ライソゾーム, リソゾーム
Norwegian Lysosom, Lysosomer
Portuguese Lisossomas, Lisossomos
Spanish lisosoma (estructura celular), lisosoma (estructura corporal), lisosoma, Lisosomas
German Lysosomen
Dutch Lysosomen, Lysosoom

Ontology: Opsonin (C0029122)

Definition (CSP) substance, generally an antibody, that makes a cell or microorgansim more susceptible to the engulfing action of phagocytes.
Definition (MSH) Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D009895
SnomedCT 6642000
English Opsonin, Opsonin Proteins [Chemical/Ingredient], opsonins, opsonin, Opsonizing antibody, Opsonin (substance), Opsonising antibody, Opsonin, NOS, Opsonins, Opsonin Proteins, Proteins, Opsonin
Swedish Opsoninproteiner
Czech opsoniny
Finnish Opsoniinit
Japanese オプソニン, オプソニン蛋白質
Polish Opsoniny
Spanish anticuerpo opsonizante, opsonina (sustancia), opsonina, Opsoninas, Proteínas Opsoninas
Portuguese Opsoninas, Proteínas Opsonizantes
German Opsonine, Opsonin-Proteine
Italian Opsonine
French Opsonines

Ontology: Phagocytes (C0031307)

Definition (MSH) Cells that can carry out the process of PHAGOCYTOSIS.
Definition (MSHCZE) Buňka schopná fagocytózy. Zejm. makrofág, mikrofág, mikroglie. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (NCI_NCI-GLOSS) A type of immune cell that can surround and kill microorganisms, ingest foreign material, and remove dead cells. It can also boost immune responses. Monocytes, macrophages, and neutrophils are phagocytes. A phagocyte is a type of white blood cell.
Definition (CSP) cells that ingest microorganisms, foreign particles, other cells, or dead tissue.
Concepts Cell (T025)
MSH D010586
SnomedCT 73568005
English Phagocytes, amebocyte, Cell, Phagocytic, Phagocyte, Cells, Phagocytic, Phagocytic Cell, Phagocytic Cells, phagocytes, cells phagocytic, phagocyte, phagocytic cell, Phagocytic cell, Phagocytic cell (cell), Phagocyte, NOS, Phagocytic cell, NOS, Phagocytic cell (body structure)
French Phagocytes, Phagocyte
Swedish Fagocyter
Czech fagocyty
Finnish Syöjäsolut
Japanese 食細胞, 喰細胞, 貪食球
Latvian Fagocīti
Polish Fagocyty, Komórki fagocytarne, Komórki żerne
Norwegian Eteceller, Fagocytter, Fagocytt
Spanish célula fagocítica, fagocito (célula), fagocito (estructura corporal), fagocito, Fagocitos
German Phagozyten
Italian Fagociti
Dutch Fagocyt, Fagocyten
Portuguese Fagócitos

Ontology: Phagosomes (C0031310)

Definition (GO) A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. [GOC:go_curators, ISBN:0198506732]
Definition (NCI) A vesicle formed by the fusion of the plasma membrane around large particles during phagocytosis.
Definition (MSH) Membrane-bound cytoplasmic vesicles formed by invagination of phagocytized material. They fuse with lysosomes to form phagolysosomes in which the hydrolytic enzymes of the lysosome digest the phagocytized material.
Concepts Cell Component (T026)
MSH D010588
SnomedCT 6023000
French Phagosomes
English phagocytic vesicle, Phagosome, Phagocytic vesicle, phagosome, Phagosomes
Swedish Fagosomer
Czech fagozómy
Finnish Fagosomit
Polish Fagosomy
Norwegian Fagosomer
Spanish fagosoma, Fagosomas
German Phagosomen
Italian Fagosomi
Dutch Fagosomen, Fagosoom
Portuguese Fagossomos

Ontology: Leukocyte-Adhesion Deficiency Syndrome (C0242597)

Definition (MSH) Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (RECEPTORS, LEUKOCYTE-ADHESION) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection.
Concepts Disease or Syndrome (T047)
MSH D018370
English Deficiency Syndrome, Leukocyte Adhesion, Leukocyte Adhesion Deficiency Syndrome, Deficiency Syndrome, Leukocyte-Adhesion, Deficiency Syndromes, Leukocyte-Adhesion, Leukocyte-Adhesion Deficiency Syndrome, Leukocyte-Adhesion Deficiency Syndromes, Syndrome, Leukocyte-Adhesion Deficiency, Syndromes, Leukocyte-Adhesion Deficiency, LEUKOCYTE ADHESION DEFIC SYNDROME, DEFIC SYNDROME LEUKOCYTE ADHESION, Leukocyte-Adhesion Deficiency Syndrome [Disease/Finding]
French Déficit d'adhérence des leucocytes, Déficit d'expression des protéines d'adhésion leucocytaires, LAD (Déficit d'Adhérence des Leucocytes), Déficit d'adhérence leucocytaire, Syndrome LAD
Czech syndrom deficience leukocytové adheze
Finnish Valkosolujen kiinnittymisvajausoireyhtymä
Swedish Leukocytadhesionsdefektsyndrom
Polish Zespół niedoboru adhezji leukocytów
Japanese 白血球接着不全, 白血球接着不全症候群, 白血球粘着不全症候群, 白血球粘着異常, 白血球粘着能欠損
Norwegian Leukocyttadhesjonsdefektsyndrom
German Leukozyten-Adhäsionsmangel-Syndrom
Italian Sindrome da deficit di adesione dei leucociti
Dutch Deficiëntiesyndroom, leukocyt-adhesie, Leukocyt-adhesie deficiëntiesyndroom, Syndroom, leukocyt-adhesie deficiëntie-
Portuguese Síndrome da Aderência Leucocítica Deficitária
Spanish Síndrome de Deficiencia de Adhesión del Leucocito

Ontology: Phagocytic cell defect (C0398730)

Concepts Disease or Syndrome (T047)
SnomedCT 234573000
English Phagocytic cell defect, Phagocytic cell defect (disorder)
Spanish defecto de célula fagocítica (trastorno), defecto de célula fagocítica

Ontology: Phagocytic cell dysfunction (C0398732)

Concepts Disease or Syndrome (T047)
SnomedCT 302874002
English phagocyte cell dysfunction, phagocyte cell dysfunction (diagnosis), Phagocytic cell dysfunction, Phagocytic cell dysfunction (disorder)
Spanish disfunción de célula fagocítica (trastorno), disfunción de célula fagocítica

Ontology: Neutrophil function disorder (C0854127)

Concepts Disease or Syndrome (T047)
Italian Disturbo della funzionalità dei neutrofili, Disturbo della funzionalità dei neutrofili NAS
Dutch neutrofielenfunctiestoornis NAO, neutrofielenfunctiestoornis
French Anomalie fonctionnelle des neutrophiles SAI, Anomalie fonctionnelle des neutrophiles
German neutrophile Funktionsstoerung NNB, Funktionsstoerung der Neutrophilen
Portuguese Perturbação da função dos neutrófilos NE, Perturbação da função dos neutrófilos
Spanish Trastorno de la función de los neutrófilos NEOM, Trastorno de la función de los neutrófilos
Japanese 好中球機能障害NOS, 好中球機能障害, コウチュウキュウキノウショウガイ, コウチュウキュウキノウショウガイNOS
Czech Poruchy funkce neutrofilů NOS, Porucha funkce neutrofilů
English Neutrophil function disorder NOS, Neutrophil function disorder
Hungarian Neutrophil funkció betegség, neutrophil funkció betegség k.m.n.