II. Definitions
- Klebsiella
- Klebsiella is a genus in the Enterobacteriaceae family
- Klebsiella species are facultatively anaerobic, nonmotile Gram-negative rods
- This page described Klebsiella Pneumoniae specifically, which is the primary pathogen in the Klebsiella genus
III. Pathophysiology
- Klebsiella Pneumoniae are facultatively anaerobic, gas forming, Gram-negative rod in Enterobacteriaceae family
- Grouped with EKP Gram Negative Bacteria (Escherichia coli, Klebsiella Pneumoniae, Proteus Mirabilis)
- Normally colonizes the oropharynx and Gastrointestinal Tract in healthy persons
- First described by Carl Friedlander in 1882, who isolated the bacterium from a deceased Pneumonia patient
- Klebsiella Pneumoniae Identifying charactistics
- Virulence factors
- Polysaccharide capsule
- Cloaks surface Opsonins (immune targets), thereby avoid Phagocytosis by Macrophages
- Lipopolysaccharide (LPS)
- Triggers a severe inflammatory response
- Fimbriae
- Allows organism to adhere to host surfaces
- Siderophores
- Harvests iron from host
- Polysaccharide capsule
- High rate of Antibiotic Resistance
IV. Associated Conditions
-
Urinary Tract Infections
- Common cause of Urinary Catheter associated Urinary Tract Infection (CAUTI, esp. hospitalized patients)
- Klebsiella Pneumonia
- See Gram Negative Pneumonia
- Increased risk in Diabetes Mellitus and Alcohol Use Disorder
- Klebsiella Pneumonia is associated with Bloody Sputum in half of cases
- Sputum appears similar to red currant jelly (due to O Antigen)
- Severe Pneumonia with cavitary lesions
- Associated with high mortality rate
-
Nosocomial Infections (3-8% of cases)
- Klebsiella Pneumoniae is among the most common causes of nosocomial Sepsis
V. Resources
- Klebsiella Pneumoniae (Stat Pearls)
VI. References
- Gladwin, Trattler and Mahan (2014) Clinical Microbiology, Medmaster, Fl, p. 75
Images: Related links to external sites (from Bing)
Related Studies
| Definition (NCI_CDISC) | Any bacterial organism that can be assigned to the species Klebsiella pneumoniae. |
| Definition (NCI) | A species of facultatively anaerobic, Gram negative, rod shaped bacteria assigned to the phylum Proteobacteria. This species is nonmotile, oxidase negative, and produces acid from glucose, mannitol, rhamnose, arabinose and amygdalin. K. ozaenae is pathogenic and a causative agent of ozena/atrophic rhinitis. |
| Definition (MSH) | Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans. |
| Definition (CSP) | gram negative, non motile, capsulated, gas producing rods found widely in nature and associated with urinary and respiratory infections in humans. |
| Concepts | Bacterium (T007) |
| MSH | D007711 |
| SnomedCT | 56415008 |
| LNC | LP102544-6 |
| English | Bacillus pneumoniae, K. pneumoniae, friedlander's bacillus, Klebsiella pneumoniae (Schroeter 1886) Trevisan 1887, KLEBSIELLA PNEUMONIAE, klebsiella pneumoniae, Klebsiella pneumoniae, Bacterium pneumoniae crouposae, Hyalococcus pneumoniae, K. PNEUMONIAE, Friedlander's bacillus, Klebsiella pneumoniae (organism) |
| Swedish | Klebsiella pneumoniae |
| Czech | Klebsiella pneumoniae |
| Finnish | Klebsiella pneumoniae |
| Japanese | クレブシエラ･ニューモニエ, 鼻硬腫菌, クレブシエラ･リノスクレロマティス, フリードレンデル菌, クレブシェラリノスクレロマチス, クレブシェラニューモニエ, 肺炎桿菌 |
| Croatian | KLEBSIELLA PNEUMONIAE |
| Polish | Pałeczki zapalenia płuc, Klebsiella pneumoniae, Pałeczki twardzieli, Klebsiella rhinoscleromatis |
| Norwegian | Klebsiella pneumoniae |
| Spanish | Klebsiella pneumoniae (organismo), bacilo de Friedlander, Klebsiella pneumoniae |
| French | Klebsiella pneumoniae, Klebsielle pneumoniae |
| German | Klebsiella pneumoniae |
| Italian | Klebsiella pneumoniae |
| Russian | KLEBSIELLA PNEUMONIAE, KLEBSIELLA RHINOSCLEROMATIS, KLEBSIELLA PNEUMONIAE SCHROETER |
| Dutch | Klebsiella pneumoniae |
| Portuguese | Klebsiella pneumoniae |
Ontology: Klebsiella (C0022727)
| Definition (CHV) | a kind of bacteria that frequently causes lung, urinary tract, intestinal, and wound infections |
| Definition (NCI) | A genus of Gram-negative, non-motile, rod-shaped bacteria that have a polysaccharide-based capsule and are oxidase negative. Klebsiella spp. are frequent human pathogens. |
| Definition (NCI_NCI-GLOSS) | A bacteria that frequently causes lung, urinary tract, intestinal, and wound infections. |
| Definition (NCI_CDISC) | Any bacteria that is not assigned to the species level but can be assigned to the Klebsiella genus level. |
| Definition (MSH) | A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection. |
| Definition (CSP) | genus of gram negative, facultatively anaerobic, rod shaped bacteria whose organisms arrange singly, in pairs, or short chains; this genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection. |
| Concepts | Bacterium (T007) |
| MSH | D007709 |
| SnomedCT | 75032006 |
| French | Klebsielles, Klebsiella |
| Swedish | Klebsiella |
| English | Klebsiella (organism), Genus Klebsiella, Genus Klebsiella (organism), klebsiella, Hyalococcus, Klebsiella Trevisan 1885 (Approved Lists 1980) emend. Carter et al. 1999, Klebsiella Trevisan 1885 (Approved Lists 1980) emend. Drancourt et al. 2001, KLEBSIELLA, Klebsiella, NOS, Klebsiella |
| Czech | Klebsiella |
| Spanish | Klebsiella (organismo), género Klebsiella (organismo), género Klebsiella, Klebsiella |
| Finnish | Klebsiella |
| Russian | KLEBSIELLY, КЛЕБСИЕЛЛЫ |
| Croatian | KLEBSIELLA |
| Polish | Klebsiella, Pałeczki otoczkowe |
| Norwegian | Klebsiella |
| German | Klebsiella |
| Italian | Klebsiella |
| Dutch | Klebsiella |
| Portuguese | Klebsiella |
