II. Pathophysiology
- Irregularly shaped Bacteria in the genus Mycoplasma, that lacks a cell wall (Penicillin resistant)
- Colonizes as well as causes symptomatic urogenital, oral and anal infections (sexually transmitted)
- Four serovars (1, 3, 6, and 14) were previously classified as Ureaplasma Urealyticum, but arre now classified as Ureaplasma Parvum
- May be associated with Mycoplasma Genitalium infections
III. Risk Factors
IV. Labs
- Difficult to culture (fastidious)
- PCR testing availability is increasing
- Urethal swabs are preferred
V. Management
- Primary Antibiotic Regimens (adult dosing)
- Doxycycline 100 mg orally or IV every 12 hours for 7 to 14 days
- Alternative Antibiotic Regimens (adult dosing)
- Azithromycin 500 mg orally or IV for 10 to 14 days OR
- Levofloxacin 500 mg orally or IV daily for 10 to 14 days OR
- Moxifloxacin 400 mg orally or IV daily for 10 to 14 days
VI. Complications
- Infertility secondary to pelvic infections (Pelvic Inflammatory Disease)
- Pregnancy loss or premature labor
- Neonatal Sepsis, Pneumonia and Meningitis may occur
- Other infections include Septic Arthritis, Osteomyelitis, Pneumonia, endocarditis
- Hyperammonemia Syndrome (Immunocompromised patients, esp. lung transplant)
VII. References
- (2024) Ureaplasma Urealyticum, Sanford Guide, accessed on IOS, 5/5/2024