II. Pathophysiology

  1. Irregularly shaped Bacteria in the genus Mycoplasma, that lacks a cell wall (Penicillin resistant)
  2. Colonizes as well as causes symptomatic urogenital, oral and anal infections (sexually transmitted)
  3. Four serovars (1, 3, 6, and 14) were previously classified as Ureaplasma Urealyticum, but arre now classified as Ureaplasma Parvum
  4. May be associated with Mycoplasma Genitalium infections

IV. Labs

  1. Difficult to culture (fastidious)
  2. PCR testing availability is increasing
    1. Urethal swabs are preferred

V. Management

  1. Primary Antibiotic Regimens (adult dosing)
    1. Doxycycline 100 mg orally or IV every 12 hours for 7 to 14 days
  2. Alternative Antibiotic Regimens (adult dosing)
    1. Azithromycin 500 mg orally or IV for 10 to 14 days OR
    2. Levofloxacin 500 mg orally or IV daily for 10 to 14 days OR
    3. Moxifloxacin 400 mg orally or IV daily for 10 to 14 days

VI. Complications

  1. Infertility secondary to pelvic infections (Pelvic Inflammatory Disease)
  2. Pregnancy loss or premature labor
  3. Neonatal Sepsis, Pneumonia and Meningitis may occur
  4. Other infections include Septic Arthritis, Osteomyelitis, Pneumonia, endocarditis
  5. Hyperammonemia Syndrome (Immunocompromised patients, esp. lung transplant)
    1. Tantengco (2021) Clin Transplant 35(7):e14334 +PMID: 33948993 [PubMed]

VII. References

  1. (2024) Ureaplasma Urealyticum, Sanford Guide, accessed on IOS, 5/5/2024

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Related Studies

Ontology: Ureaplasma urealyticum (bacteria) (C0085501)

Definition (NCI_CDISC) Any bacterial organism that can be assigned to the species Ureaplasma urealyticum.
Definition (NCI) A species of irregularly shaped bacteria that does not contain a cell well in the phylum Tenericutes. This species is urease and acid phosphatase positive and hexokinase and catalase negative; sterols are required for growth. U. urealyticum resides in the genital flora of humans and may be a cause of urogenital infections.
Definition (MSH) A species of gram-negative bacteria found in the human genitourinary tract (UROGENITAL SYSTEM), oropharynx, and anal canal. Serovars 1, 3, 6, and 14 have been reclassed into a separate species UREAPLASMA parvum.
Concepts Bacterium (T007)
MSH D016990
SnomedCT 12006007
LNC LP19253-1, MTHU007821, LA18630-6
English Ureaplasma urealyticum, Ureaplasma urealyticum (bacteria), Ureaplasma urealyticum Shepard et al. 1974 (Approved Lists 1980) emend. Robertson et al. 2002, T-Mycoplasma, ureaplasma urealyticum, urealyticum ureaplasma, Ureaplasma urealyticum biovar 2, T-MYCOPLASMA, UREAPLASMA UREALYTICUM, T-mycoplasma, Ureaplasma urealyticum (organism)
French Ureaplasma urealyticum biovar 2, Ureaplasma urealyticum
Swedish Ureaplasma urealyticum
Czech Ureaplasma urealyticum
Finnish Ureaplasma urealyticum
Japanese ウレアプラズマ・ウレアリティカム
Croatian UREAPLASMA UREALYTICUM
Polish Ureaplasma urealyticum
Norwegian Ureaplasma urealyticum biovar 2, Ureaplasma urealyticum
Spanish Ureaplasma urealyticum (organismo), Ureaplasma urealyticum
German Ureaplasma urealyticum
Italian Ureaplasma urealyticum
Russian UREAPLASMA UREALYTICUM
Dutch Ureaplasma urealyticum
Portuguese Ureaplasma urealyticum

Ontology: Ureaplasma parvum (C1065064)

Definition (MSH) A species of UREAPLASMA containing four serovars formerly classed as UREAPLASMA UREALYTICUM. Those serovars are 1, 3, 6, and 14.
Concepts Bacterium (T007)
MSH D014509
SnomedCT 438391000
LNC LP145575-9, LA19122-3
French Ureaplasma urealyticum biovar 1, Ureaplasma parvum
Portuguese Ureaplasma parvum
German Ureaplasma parvum, Ureaplasma urealyticum biovar 1
English Ureaplasma parvum (organism), Ureaplasma parvum Robertson et al. 2002, Ureaplasma urealyticum biovar 1, Ureaplasma parvum
Spanish Ureaplasma parvum, Ureaplasma parvum (organismo)
Italian Ureaplasma parvum, Ureaplasma urealyticum biovar 1
Norwegian Ureaplasma urealyticum biovar 1, Ureaplasma parvum
Dutch Ureaplasma parvum