Mycoplasma Genitalium

Aka: Mycoplasma Genitalium

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II. Pathophysiology

  1. Gram Negative Bacteria found in genitourinary tract as a Sexually Transmitted Infection
  2. Causes Non-Gonococcal Urethritis

III. Associated Conditions

  1. Non-Gonococcal Urethritis
  2. Cervicitis
  3. Pelvic Inflammatory Disease

IV. Labs

  1. Screening Indications
    1. Symptomatic patients with Urethritis or Cervicitis
    2. Pelvic Inflammatory Disease (consider)
    3. Persistent Epididymitis
    4. Avoid testing in isolated Vaginal Discharge
  2. Mycoplasma Genitalium PCR (NAAT)
    1. Obtain sample from first void urine sample, vulvovaginal swab or rectal swab
    2. Reflex Macrolide resistance testing is available from some labs

V. Management

  1. Macrolide Resistance (or unknown, testing unavailable)
    1. First: Doxycycline 100 mg orally twice daily for 7 days
    2. Next: Moxifloxacin (Avelox) 400 mg orally daily for 7 days
  2. Macrolide Sensitive
    1. First: Doxycycline 100 mg orally twice daily for 7 days
    2. Next: Azithromycin 1000 mg on Day 1, then 500 mg daily on days 2, 3 and 4

VI. References

  1. Manhart (2011) Clin Infect Dis 53 Suppl 3(Suppl 3):S129-42 +PMID: 22080266 [PubMed]
  2. Workowski (2021) MMWR Recomm Rep 70(4): 1-187 [PubMed]

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Related Studies

Ontology: Mycoplasma genitalium (C0317872)

Definition (MSH) A species of gram-negative bacteria originally isolated from urethral specimens of patients with non-gonoccocal URETHRITIS. In primates it exists in parasitic association with ciliated EPITHELIAL CELLS in the genital and respiratory tracts.
Definition (CSP) species of gram negative bacteria originally isolated from urethral specimens of patients with non-gonoccocal urethritis; in primates it exists in parasitic association with ciliated epithelial cells in the genital and respiratory tracts.
Concepts Bacterium (T007)
MSH D045704
SnomedCT 5056007
LNC LP145574-2
Swedish Mycoplasma genitalium
Czech Mycoplasma genitalium
Finnish Mycoplasma genitalium
English Mycoplasma genitalium Tully et al. 1983, Mycoplasma genitalium, Mycoplasma genitalium (organism)
Polish Mycoplasma genitalium
Norwegian Mycoplasma genitalium
Croatian MYCOPLASMA GENITALIUM
Spanish Mycoplasma genitalium (organismo), Mycoplasma genitalium
French Mycoplasma genitalium
German Mycoplasma genitalium
Italian Mycoplasma genitalium
Russian MYCOPLASMA GENITALIUM
Dutch Mycoplasma genitalium
Portuguese Mycoplasma genitalium
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Sexually Transmitted Disease

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