II. Pathophysiology
- Reaction occurs with treatment of Spirochete infection
- Syphilis (reaction occurs variably based on stage)
- Primary Syphilis: 50%
- Secondary Syphilis: 90%
- Latent Syphilis: 25%
- Relapsing Fever (Tick-Borne Disease)
- Syphilis (reaction occurs variably based on stage)
III. Signs and Symptoms
-
General
- Fever
- Adenopathy
- Skin rash
- Arthralgias
- Malaise
- Diaphoresis
- Neurologic symptoms
IV. Course
- Occurs 2 to 6 hours after treatment started
- Symptoms last for 24 hours
V. Management
- Acetaminophen 2 hours before and after Antibiotic dose
- Corticosteroids and NSAIDs do not prevent complications
- Maintain hydration
VI. References
- Kirk, McHugh and Parnell (2023) Crit Dec Emerg Med 37(8): 23-9
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Related Studies
Concepts | Injury or Poisoning (T037) |
SnomedCT | 10803007 |
English | Herxheimer's reaction, Herxheimer reaction, Jarisch-Herxheimer reaction (diagnosis), Jarisch-Herxheimer reaction, herxheimer reaction, jarisch-herxheimer reaction, herxheimer's reaction, jarisch herxheimer reaction, herxheimer reactions, herxheimer jarisch reaction, Jarisch Herxheimer reaction, Jarisch Herxheimer reaction (disorder), Herxheimer; reaction, Herxheimer, reaction; Herxheimer |
Italian | Reazione di Jarisch-Herxheimer, Reazione di Herxheimer |
Dutch | Herxheimer-reactie, Herxheimer; reactie, reactie; Herxheimer, Jarisch-Herxheimer-reactie |
German | Herxheimer-Reaktion, Jarisch-Herxheimer-Reaktion |
Portuguese | Reacção de Herxheimer, Reacção de Jarisch-Herxheimer |
Spanish | Reacción de Herxheimer, reacción de Herxheimer (trastorno), reacción de Herxheimer, reacción de Jarisch Herxheimer (trastorno), reacción de Jarisch Herxheimer, Reacción de Jarisch-Herxheimer |
Japanese | ヤーリッシュ・ヘルクスハイマー反応, ヘルクスハイマー反応, ヘルクスハイマーハンノウ, ヤーリッシュヘルクスハイマーハンノウ |
French | Réaction d'Herxheimer, Réaction de Jarisch-Herxheimer |
Czech | Jarisch-Herxheimerova reakce, Herxheimerova reakce |
Hungarian | Herxheimer-reakció, Jarisch-Herxheimer-reakció |