II. Background

  1. Manifestation of Tertiary Syphilis

III. Pathophysiology

  1. Arterial wall medial necrosis and loss of elastic fibers
  2. Typically affects aorta but may affect any part of the Cardiovascular System

IV. Course

  1. Begins 5 to 10 years after initial infection
  2. Clinically seen 20-30 years after infection

V. Signs

  1. Obliterative endarteritis of vasa vasorum
  2. Ascending aorta develops
    1. Aortic Insufficiency
    2. Aortic aneurysm

VI. Labs

VII. Management

VIII. Complications

  1. Aortic Insufficiency
  2. Aorta Rupture

IX. References

  1. Kirk, McHugh and Parnell (2023) Crit Dec Emerg Med 37(8): 23-9
  2. Green, Cohen, Billington (2016) Crit Dec Emerg Med 30(11): 4-10

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