II. Mechanism
- Neutrophil Granulocytes contain esterases
- Positive test suggests pyuria
- Dipstick requires 5 minutes to change color
III. Interpretation: Normal
- Negative
IV. Interpretation: Positive (Abnormal)
- Urinary Tract Infection
- Sexually Transmitted Infection
- Vaginal contaminant
V. Causes: False NegativeLeukocyte esterase on Urinalysis
- Inadequate time allowed for dipstick reading (60 to 120 seconds)
- Increased Urine Specific Gravity
- Urine Glucose present (Glycosuria)
- Urine Ketones present (Ketonuria)
- Urine Protein present (Proteinuria)
- Vitamin C
- Enterococcus UTI
- Klebsiella UTI
-
Antibiotics
- Cefalexin (Keflex)
- Nitrofurantoin (Macrobid)
- Tetracycline
- Gentamicin
VI. Causes: Positive Leukocyte esterase and negative Urine Culture
- Chlamydia
- Ureaplasma Urealyticum
- Balanitis
- Bladder Cancer
- Nephrolithiasis
- Tuberculosis
- Urinary tract foreign body
- Glomerulonephritis
- Medications (Corticosteroid, Cytoxan)
- Methenamine