II. Mechanism

  1. Free PSA increases more in Benign Prostatic Hypertrophy
  2. PSA associated with cancer is more Protein bound

III. Indication

  1. Detection of Prostate Cancer when PSA 2.5 to 10 ng/ml

IV. Efficacy

  1. Improved Specificity when combined with PSA

V. Interpretation

  1. Free PSA >27% with lower likelihood of Prostate Cancer
  2. Values suggestive of Prostate Cancer
    1. Total PSA 3.0 to 4.0 with Free PSA <19%
    2. Total PSA 4.0 to 10.0 with Free PSA <17 to 24%

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