II. Mechanism
- Free PSA increases more in Benign Prostatic Hypertrophy
- PSA associated with cancer is more Protein bound
III. Indication
- Detection of Prostate Cancer when PSA 2.5 to 10 ng/ml
IV. Efficacy
- Improved Specificity when combined with PSA
V. Interpretation
- Free PSA >27% with lower likelihood of Prostate Cancer
- Values suggestive of Prostate Cancer
- Total PSA 3.0 to 4.0 with Free PSA <19%
- Total PSA 4.0 to 10.0 with Free PSA <17 to 24%