II. Background
- Bilirubin testing on the Urine Dipstick reflects tests for 2 different related compounds
-
Conjugated Bilirubin
- Unconjugated Bilirubin is not soluble in water and is not found in the urine
- Conjugated Bilirubin is excreted in the stool under normal conditions
- Conjugated Bilirubin is an abnormal finding in the urine and reflects liver disease (or False Positive)
- Ictotest can be run as a confirmatory test for urine Conjugated Bilirubin
- Urobilinogen
III. Causes: Urine Conjugated Bilirubin
- True Positive Test
- Biliary tract obstruction
- Hepatitis
- Viral Hepatitis
- Toxic Hepatitis
- Drug Induced Hepatitis
- Confirmatory Findings of Positive Test
- Ictotest Positive
- Gross urine findings if Conjugated Bilirubin present
- Dark Urine with yellow foam
- Sediment elements may be stained
-
False Positive
Bilirubin (Ictotest Negative)
- Chlorpromazine (Thorazine)
- Phenazopyridine (Pyridium)
- False Negative Bilirubin
IV. Causes: Urobilinogen
- True Positive Urobilinogen
- Trace or Small Urobilinogen may be a normal finding
- Hepatitis
- Liver disease
- Hemolytic Jaundice
-
False Positive Urobilinogen
- Phenazopyradine (Pyridium)
- Sulfonamides
-
False Negative Tests
- Inadequate urine sample storage
- Preservatives present in urine sample
Images: Related links to external sites (from Bing)
Related Studies
Definition (MSH) | A colorless compound formed in the intestines by the reduction of bilirubin. Some is excreted in the feces where it is oxidized to urobilin. Some is reabsorbed and re-excreted in the bile as bilirubin. At times, it is re-excreted in the urine, where it may be later oxidized to urobilin. |
Concepts | Biologically Active Substance (T123) , Organic Chemical (T109) |
MSH | D014558 |
SnomedCT | 44079009 |
LNC | LP15942-3, MTHU003204 |
English | 21H-Biline-8,12-dipropanoic acid, 2,17-diethyl-1,4,5,10,15,16,19,22,23,24-decahydro-3,7,13,18-tetramethyl-1,19-dioxo-, Urobilinogen [Chemical/Ingredient], urobilinogens, urobilinogen, Urobilinogen, UBG - Urobilinogen, UROB - Urobilinogen, Urobilinogen (substance), Urobilinogen, NOS |
Swedish | Urobilinogen |
Czech | urobilinogen |
Finnish | Urobilinogeeni |
Russian | UROBILINOGEN, УРОБИЛИНОГЕН |
Polish | Urobilinogen |
Spanish | urobilinógeno (sustancia), urobilinógeno, Urobilinógeno |
French | Urobilinogène |
German | Urobilinogen |
Italian | Urobilinogeno |
Portuguese | Urobilinogênio |
Ontology: Bilirubin in urine (C0555166)
Concepts | Laboratory or Test Result (T034) |
SnomedCT | 275778006, 144738003, 167514002, 273691000009105 |
English | Urine bilirubin, Urine bilirubin level, Bilirubin in urine, Finding of bilirubin in urine, urine bilirubin, bilirubin in urine, (Urine bilirubin) or (bilirubin in urine) (procedure), (Urine bilirubin) or (bilirubin in urine), Bilirubinuria, Bilirubin levels in urine above normal, Bilirubin levels in urine above normal (finding), Finding of bilirubin in urine (finding), Bilirubin in urine - finding |
Italian | Bilirubinuria |
Japanese | ビリルビン尿, ビリルビンニョウ |
Czech | Bilirubinurie |
Hungarian | bilirubinuria |
Spanish | bilirrubina en orina - hallazgo (hallazgo), bilirrubina en orina - hallazgo, Bilirrubinuria |
Portuguese | Bilirrubinúra |
Dutch | bilirubinurie |
French | Bilirubinurie |
German | Bilirubinurie |