II. Types: Direct Hepatotoxins (Onset within 48 hours)
- Signs
- Biopsy with necrosis at terminal hepatic venule
- Causes
- See Hepatotoxin
- Carbon tetrachloride
- Benzene derivative
- Mushroom Poisoning
- Herbal Toxicity
- Antiepileptics
- Amiodarone
- Methotrexate
- Acetaminophen (42% of acute liver injury in U.S.)
- Antibiotics (second most common cause in U.S.)
- Amoxicillin-clavulanate
- Trimethoprim-sulfamethoxazole
- Isoniazid
- Nitrofurantoin
III. Types: Idiosyncratic Reaction (Variable onset)
- Signs
- Causes
IV. Resources
- See Hepatotoxin
- NIDDK/NLM Liver Tox
V. References
Images: Related links to external sites (from Bing)
Related Studies
| Definition (MSH) | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. |
| Concepts | Injury or Poisoning (T037) |
| MSH | D006523 , D056486 |
| SnomedCT | 197352008 |
| French | HEPATITE TOXIQUE, Hépatite toxique |
| English | HEPATITIS TOXIC, Hepatitis toxic, HEPATITIS TOX, Hepatitis, Toxic, TOX HEPATITIS, Hepatitides, Toxic, Toxic Hepatitides, Toxic Hepatitis, toxic hepatitis, hepatitis toxic, Toxic hepatitis, Toxin-associated hepatitis, Toxic hepatitis (disorder), hepatitis; toxic, toxic; hepatitis |
| Portuguese | HEPATITE TOXICA, Hepatite tóxica |
| Spanish | HEPATITIS TOXICA, hepatitis asociada a toxinas, hepatitis tóxica (trastorno), hepatitis tóxica, Hepatitis tóxica |
| Japanese | 中毒性肝炎, ﾁｭｳﾄﾞｸｾｲｶﾝｴﾝ |
| Finnish | Toksinen maksatulehdus |
| German | HEPATITIS TOXISCH, Hepatitis, toxische, Toxische Hepatitis, Hepatitis toxisch |
| Czech | Toxická hepatitida, hepatitida toxická |
| Italian | Epatite tossica |
| Hungarian | Toxikus hepatitis |
| Norwegian | Toksisk hepatitt, Hepatitt, toksisk |
| Dutch | hepatitis; toxisch, toxisch; hepatitis, hepatitis toxisch, Hepatitis, toxische, Toxische hepatitis |
Ontology: Toxic liver disease (C0348754)
| Concepts | Disease or Syndrome (T047) |
| ICD10 | K71.9 , K71 |
| SnomedCT | 197354009, 197363006, 197558006 |
| English | Toxic liver disease, unspecified, Toxic liver disease,unspec, [X]Toxic liver disease, unspecified, [X]Toxic liver disease,unspec, liver toxic disorder, Hepatotoxicity, toxic liver disease (diagnosis), [X]Toxic liver disease, unspecified (disorder), Hepatic toxicity, Hepatic intoxication, Toxic liver disease (disorder), disease (or disorder); liver, toxic, Toxic liver disease |
| Spanish | hepatotoxicidad, [X]enfermedad tóxica hepática, no especificada, [X]enfermedad tóxica hepática, no especificada (trastorno), hepatopatía tóxica (trastorno), hepatopatía tóxica |
| German | Toxische Leberkrankheit, nicht naeher bezeichnet, Toxische Leberkrankheit |
| Korean | 상세불명의 독성 간질환, 독성 간질환 |
| Dutch | aandoening; lever, toxisch, Toxische leverziekte, niet gespecificeerd, Toxische leverziekte |
Ontology: Hepatitis, Drug-Induced (C1262760)
| Concepts | Disease or Syndrome (T047) |
| MSH | D056486 , D006523 |
| SnomedCT | 235876009 |
| English | Hepatitis, Drug-Induced, Hepatitis, Drug Induced, Drug-Induced Hepatitides, Drug-Induced Hepatitis, Hepatitides, Drug-Induced, HEPATITIS DRUG IND, drug-induced hepatitis, drug hepatitis induced, drug induced hepatitis, hepatitis drug induced, Hepatitis drug-induced, Drug-induced hepatitis, Drug-induced hepatitis (disorder) |
| French | Hépatite toxique due aux médicaments, Hépatite d'origine médicamenteuse, Hépatite médicamenteuse, Hépatite induite par les médicaments |
| German | Hepatitis, arzneimittelinduzierte, Arzneimittelhepatitis, von Arzneimitteln verursachte Hepatitis, Hepatitis, von Arzneimitteln verursacht |
| Italian | Epatite indotta da farmaci, Epatite da farmaci |
| Czech | hepatitida vyvolaná léky, Poléková hepatitida |
| Dutch | geneesmiddelengeïnduceerde hepatitis, hepatitis geneesmiddelengeïnduceerd, Hepatitis ten gevolge van geneesmiddel |
| Hungarian | Gyógyszer-által kiváltott hepatitis, Gyógyszer által kiváltott hepatitis |
| Spanish | Hepatitis inducida por fármacos, hepatitis inducida por drogas, hepatitis inducida por medicamentos (trastorno), hepatitis inducida por medicamentos |
| Japanese | 薬剤誘発性肝炎, ﾔｸｻﾞｲﾕｳﾊﾂｾｲｶﾝｴﾝ |
| Portuguese | Hepatite farmacoinduzida |
| Norwegian | Medikamentelt betinget hepatitt, Legemiddelutløst hepatitt, Medikamentelt indusert hepatitt, Medikamentindusert hepatitt, Medikamentelt utløst hepatitt |
