II. Epidemiology
- Enteric transmission of non-A, non-B Hepatitis
- Most common cause in world
-
Waterborne Illness epidemics in
- India
- Asia
- Africa
- Mexico
III. Course
- Self-limited illness
- Mortality 10-20% in pregnant women
- No associated chronic hepatitis
IV. Pathophysiology
- Incubation Period: 15-60 days (mean 40 days)
- Infectivity: Virus excretion in stool for <14 days
- Calicivirus (diameter 32-34 nm))
V. Signs and Symptoms
- See Viral Hepatitis
VI. Differential Diagnosis
VII. Management
- High calorie diet (better tolerated in morning)
- IV Hydration when indicated for severe Dehydration
- Cholestyramine up to 4g PO qid for severe Pruritus
- Avoid drugs with hepatic metabolism