II. Epidemiology

  1. Enteric transmission of non-A, non-B Hepatitis
    1. Most common cause in world
  2. Waterborne Illness epidemics in
    1. India
    2. Asia
    3. Africa
    4. Mexico

III. Course

  1. Self-limited illness
  2. Mortality 10-20% in pregnant women
  3. No associated chronic hepatitis

IV. Pathophysiology

  1. Incubation Period: 15-60 days (mean 40 days)
  2. Infectivity: Virus excretion in stool for <14 days
  3. Calicivirus (diameter 32-34 nm))

V. Signs and Symptoms

VI. Differential Diagnosis

VII. Management

  1. High calorie diet (better tolerated in morning)
  2. IV Hydration when indicated for severe Dehydration
  3. Cholestyramine up to 4g PO qid for severe Pruritus
  4. Avoid drugs with hepatic metabolism

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