Definition (NCI)
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Expressed primarily by human SST Gene (Somatostatin Family) in the hypothalamic median eminence and in pancreatic delta cells, secreted 116-aa 13-kDa (precursor) Somatostatin is an important cyclic tetradecapeptide regulator of endocrine and nervous system function. Somatostatin inhibits release of adenohypophyseal GH, thyrotropin, and corticotropin, pancreatic insulin and glucagon, gastric mucosal gastrin, intestinal mucosal secretin, and renal renin by binding to specific high-affinity cell surface G protein-coupled receptors expressed in a tissue-specific manner. (NCI)
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Definition (CSP)
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any of several cyclic tetradecapeptides elaborated primarily by the median eminence of the hypothalamus and by the delta cells of the pancreatic islets; they inhibit release of a variety of hormones, including growth hormone, thyrotropin, corticotropin, insulin, glucagon, gastrin, secretin and renin.
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Definition (MSH)
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A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
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Concepts |
Amino Acid, Peptide, or Protein
(T116)
, Hormone
(T125)
, Pharmacologic Substance
(T121)
|
MSH |
D013004
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SnomedCT |
49722008, 47422003, 259352009, 57819002 |
LNC |
LP14694-1, MTHU013968 |
English |
Somatostatin, Somatostatin 14, Somatostatin-14, Somatotropin Release Inhibiting Hormone, SRIH-14, Cyclic Somatostatin, Somatostatin, Cyclic, Somatotropin Release-Inhibiting Hormone, Growth horm release inhib horm, Growth Hormone Release Inhibiting Factor, Somatotropin Release Inhibiting Factors, Panhibin, Somatotropin Release Inhibiting Factor, Somatotropin Release-Inhibiting Factor, SOMATOSTATIN 014, SOMATOTROPIN RELEASE INHIB HORMONE, GIF (growth hormone release inhibiting factor), growth hormone release inhibiting factor, somatostatin (medication), Somatostatin [Chemical/Ingredient], somatostatins, srif, somatostatin, Somatostatin-14 (substance), Somatotropin inhibiting factor preparation (product), SOMATOSTATIN, Growth hormone inhibiting factor, SRIF, Somatostatin preparation, Somatotropin inhibiting factor preparation, Somatotropin release inhibiting factor, Growth hormone release inhibiting hormone, SS - Somatostatin, Somatostatin (substance), Somatostatin preparation (product), SIF preparation, Somatostatin preparation (substance), Somatotropin inhibiting factor preparation -RETIRED-, Growth Hormone Inhibitor, SST, Growth Hormone-Inhibiting Hormone |
German |
Somatotropin-Release-Inhibiting-Faktor, SOMATOSTATIN 014, SRIH, Somatostatin-14, Somatostatin, Zyklisches Somatostatin, Somatotropin-Release-Inhibiting-Hormon |
French |
SRIF-14, Somatostatine-14, Somatostatine 14, Somatostatine cyclique, Hormone inhibant la libération de la somatotropine, Hormone inhibant la libération de la somatotrophine, Facteur inhibant la libération de la somatotropine, Facteur inhibant la libération de la somatotrophine, Somatostatine |
Swedish |
Somatostatin
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Czech |
somatostatin
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Finnish |
Somatostatiini
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Italian |
Somatostatina-14, Somatostatina ciclica, Ormone inibitore del rilascio di somatotropina, Fattore inibitore del rilascio di somatotropina, SRIH-14, Somatostatina |
Russian |
SOMATOSTATIN-14, SOMATOSTATIN, SOMATOTROPIN-INGIBIRUIUSHCHII GORMON, SOMATOTROPNYI GORMON-INGIBIRUIUSHCHII FAKTOR, СОМАТОСТАТИН-14, СОМАТОСТАТИН, СОМАТОТРОПИН-ИНГИБИРУЮЩИЙ ГОРМОН, СОМАТОТРОПНЫЙ ГОРМОН-ИНГИБИРУЮЩИЙ ФАКТОР |
Spanish |
somatostatina (producto), preparado con somatostatina (producto), somatostatina, preparado con somatostatina, somatostatina-14, preparado de factor inhibidor de somatotrofina-RETIRADO-, preparado de SIF, preparado de factor inhibidor de somatotropina, preparado de factor inhibidor de somatotrofina-RETIRADO- (concepto no activo), somatostatina-14 (sustancia), factor inhibidor de la hormona del crecimiento, factor inhibidor de la liberación de STH, factor inhibidor de la liberación de somatotrofina (sustancia), factor inhibidor de la liberación de somatotrofina, preparado de somatostatina (producto), preparado de somatostatina (sustancia), preparado de somatostatina, Somatostatina, Somatostatina-14, Hormona Inhibidora de Liberación de Somatotropina, Somatostatina Cíclica |
Croatian |
SOMATOSTATIN
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Polish |
Somatostatyna, Hormon hamujący uwalnianie somatotropiny |
Japanese |
サイクリックソマトスタチン, 成長ホルモン放出抑制ホルモン, ソマトスタチン-14, ソマトスタチン, ソマトトロピン放出抑制因子, 成長ホルモン放出抑制因子 |
Norwegian |
SRIH-14, Somatostatin-14, Syklisk somatostatin, Somatostatin, Somatostatin, syklisk |
Portuguese |
Hormônio Inibidor da Liberação de Somatotropina, Somatostatina 14, Somatostatina Cíclica, Somatostatina |