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Ontology:
Ondansetron
(C0061851)
Definition (NCI)
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A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)
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Definition (NCI_NCI-GLOSS)
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The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Ondansetron is a type of serotonin receptor antagonist and a type of antiemetic.
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Definition (MSH)
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A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
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Definition (CSP)
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competitive serotonin type 3 receptor antagonist used in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs; also has anxiolytic and neuroleptic properties.
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Definition (PDQ)
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A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40693&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40693&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1119" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D017294
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SnomedCT |
108418007, 372487007 |
LNC |
LP171625-9 |
English |
4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, ondansetron, ondansetron (medication), ONDANSETRON, Ondansetron [Chemical/Ingredient], ONAD, Ondansetron, Ondansetron, (+,-)-Isomer, Ondansetron (product), Ondansetron (substance) |
Swedish |
Ondansetron
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Czech |
ondansetron
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Finnish |
Ondansetroni
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Russian |
ONDANSETRON, ОНДАНСЕТРОН |
Japanese |
オンダンセトロン
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Croatian |
ONDANSETRON
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Spanish |
ondansetrona, ondansetrón (producto), ondansetrona (producto), ondansetrona (sustancia), ondansetrón (sustancia), ondansetrón, Ondansetrón |
Polish |
Ondansetron
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French |
Ondansétron
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German |
Ondansetron
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Italian |
Ondansetrone
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Portuguese |
Ondansetron
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Ontology:
Granisetron
(C0061863)
Definition (NCI_NCI-GLOSS)
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The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Granisetron is a type of serotonin receptor antagonist and a type of antiemetic.
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Definition (NCI)
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An indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
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Definition (MSH)
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A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D017829
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SnomedCT |
108424001, 372489005 |
English |
1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, endo-, granisetron, 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide, Granisetron [Chemical/Ingredient], Granisetron Transdermal System, 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide, GRANISETRON, Granisetron product, Granisetron (product), Granisetron (substance), GRAN, Granisetron |
Swedish |
Granisetron
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Czech |
granisetron
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Finnish |
Granisetroni
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Russian |
GRANISETRON, ГРАНИСЕТРОН |
Japanese |
グラニセトロン
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Spanish |
granisetrón (producto), granisetrona (producto), granisetrona, granisetrona (sustancia), granisetrón (sustancia), granisetrón, Granisetrón |
Polish |
Granisetron
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French |
Granisétron
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German |
Granisetron
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Italian |
Granisetrone
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Portuguese |
Granisetron
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Ontology:
Kytril
(C0107189)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D017829
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English |
kytril, Kytril |
Ontology:
Zofran
(C0206046)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D017294
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English |
zofran, Zofran |
Ontology:
Dolasetron
(C0209210)
Definition (NCI_NCI-GLOSS)
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The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Dolasetron is a type of serotonin receptor antagonist and a type of antiemetic.
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Definition (NCI)
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An indole derivative and a potent serotonin 5-HT3 receptor antagonist with anti-emetic property. Dolasetron blocks the activity of serotonin released from the enterochromaffin cells of the small intestine by selectively inhibiting and inactivating 5-HT3 receptors located on the nerve terminals of the vagus nerve in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. This results in suppression of signalling to trigger chemo- and radiotherapy induced nausea and vomiting.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C060344
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SnomedCT |
108421009, 372488002 |
English |
octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate, DOLASETRON, dolasetron, Dolasetron, Dolasetron (product), Dolasetron (substance) |
Spanish |
dolasetrón (producto), dolasetrona, dolasetrona (producto), dolasetrona (sustancia), dolasetrón (sustancia), dolasetrón |
Ontology:
palonosetron
(C0220578)
Definition (NCI_NCI-GLOSS)
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The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Palonosetron is a type of serotonin receptor antagonist and a type of antiemetic.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C083418
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SnomedCT |
404851001, 404852008 |
English |
2-QHBIQO, 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one, palonosetron [Chemical/Ingredient], palonosetron, PALONOSETRON, Palonosetron (product), Palonosetron (substance), Palonosetron |
Spanish |
palonosetrón (sustancia), palonosetron (sustancia), palonosetron, palonosetrón (producto), palonosetrón |
Ontology:
Anzemet
(C0718607)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C060344
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English |
Anzemet, anzemet |
Ontology:
Aloxi
(C1310735)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C083418
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English |
Aloxi, aloxi |
Ontology:
Serotonin 5-HT3 Receptor Antagonists
(C2936526)
Definition (MSH)
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Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.
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Concepts |
Pharmacologic Substance
(T121)
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MSH |
D058831
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English |
5-HT3 Antagonist, Antagonist, 5-HT3, Antagonists, 5-HT3, Serotonin 5-HT3 Receptor Antagonists, Serotonin 5 HT3 Receptor Antagonists, 5-HT3 Antagonists, 5 HT3 Antagonists, 5 HT3 Antagonist |
French |
Antagonistes des récepteurs 5-HT3 de la sérotonine, Antagonistes 5-HT3 |
German |
5-HT3-Antagonisten, 5-HT3-Antagonist, Serotonin-5-HT3-Rezeptorantagonisten |
Czech |
serotoninové 5-HT3 receptory - antagonisté, serotoninové receptory 5-HT3 - antagonisté, 5-HT3 antagonisté |
Spanish |
Antagonistas del Receptor de Serotonina 5-HT3
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Russian |
СЕРОТОНИНА 5-HT3 РЕЦЕПТОРОВ АНТАГОНИСТЫ, SEROTONINA 5-HT3 RETSEPTOROV ANTAGONISTY |
Portuguese |
Antagonistas do Receptor 5-HT3 de Serotonina
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Polish |
Antagoniści receptora serotoninowego 5-HT3
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Italian |
Antagonisti dei recettori della serotonina 5-HT3
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