Olsalazine

Aka: Olsalazine, Dipentum

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II. Indications

  1. Ulcerative Colitis

III. Mechanism

  1. Diazo-Bonded 5-ASA product
  2. Olsalazine is a prodrug that is retained in the colon and metabolized to 5-Aminosalicylic Acid
    1. Oral agent converted to active 5-ASA (Mesalamine) by Bacteria within the colon

IV. Dosing: Adult

  1. Induction: 1.5 to 3 g/day divided twice daily
  2. Maintain: 500 mg orally twice daily with food
    1. As of 2022, >$1500/month

V. Adverse Effects

  1. Diarrhea (17 to 20%)
    1. Balsalazide has similar mechanism of action, but less Diarrhea (better tolerated)

VI. Safety

  1. Pregnancy Category C
  2. Avoid in Lactation

VII. Resources

  1. Olsalazine - Dipentum (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8512d0c6-db4e-4673-b3b4-28975c18413f

VIII. References

  1. (2022) Treatment of Mild to Moderate Ulcerative Colitis, Presc Lett, #350406
  2. (2023) Drugs for Inflammatory Bowel Disease, Med Lett Drug Ther 65: 105-12

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