II. Indications

III. Mechanism

  1. Diazo-Bonded 5-ASA product
  2. Olsalazine is a prodrug that is retained in the colon and metabolized to 5-Aminosalicylic Acid
    1. Oral agent converted to active 5-ASA (Mesalamine) by Bacteria within the colon

IV. Dosing: Adult

  1. Induction: 1.5 to 3 g/day divided twice daily
  2. Maintain: 500 mg orally twice daily with food
    1. As of 2022, >$1500/month

V. Adverse Effects

  1. Diarrhea (17 to 20%)
    1. Balsalazide has similar mechanism of action, but less Diarrhea (better tolerated)

VI. Safety

  1. Pregnancy Category C
  2. Avoid in Lactation

VIII. References

  1. (2022) Treatment of Mild to Moderate Ulcerative Colitis, Presc Lett, #350406
  2. (2023) Drugs for Inflammatory Bowel Disease, Med Lett Drug Ther 65: 105-12

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Ontology: olsalazine (C0069454)

Definition (NCI) A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C032587
SnomedCT 363631003, 108673002, 386890003
English azodisalicylate, olsalazine, C.I. Mordant Yellow 5, 3,3'-Azobis[6-hydroxybenzoic Acid], 3,3'-Dicarboxy-4,4'-dihydroxyazobenzene, olsalazine [Chemical/Ingredient], Olsalazine product, Olsalazine product (substance), Azodisalicylic acid, Olsalazine, Olsalazine (product), Olsalazine (substance), Benzoic acid, 3,3'-azobis(6-hydroxy)-,, Azodisalicylate, OLSALAZINE
Spanish olsalacina (producto), olsalazina (producto), olsalacina, olsalazina, producto (sustancia), olsalazina, producto, olsalacina (sustancia), olsalazina (sustancia), olsalazina