II. Indications
III. Mechanism
- Diazo-Bonded 5-ASA product
- Olsalazine is a prodrug that is retained in the colon and metabolized to 5-Aminosalicylic Acid
- Oral agent converted to active 5-ASA (Mesalamine) by Bacteria within the colon
IV. Dosing: Adult
- Induction: 1.5 to 3 g/day divided twice daily
- Maintain: 500 mg orally twice daily with food
- As of 2022, >$1500/month
V. Adverse Effects
-
Diarrhea (17 to 20%)
- Balsalazide has similar mechanism of action, but less Diarrhea (better tolerated)
VI. Safety
- Pregnancy Category C
- Avoid in Lactation
VII. Resources
- Olsalazine - Dipentum (DailyMed)
VIII. References
- (2022) Treatment of Mild to Moderate Ulcerative Colitis, Presc Lett, #350406
- (2023) Drugs for Inflammatory Bowel Disease, Med Lett Drug Ther 65: 105-12
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Definition (NCI) | A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C032587 |
SnomedCT | 363631003, 108673002, 386890003 |
English | azodisalicylate, olsalazine, C.I. Mordant Yellow 5, 3,3'-Azobis[6-hydroxybenzoic Acid], 3,3'-Dicarboxy-4,4'-dihydroxyazobenzene, olsalazine [Chemical/Ingredient], Olsalazine product, Olsalazine product (substance), Azodisalicylic acid, Olsalazine, Olsalazine (product), Olsalazine (substance), Benzoic acid, 3,3'-azobis(6-hydroxy)-,, Azodisalicylate, OLSALAZINE |
Spanish | olsalacina (producto), olsalazina (producto), olsalacina, olsalazina, producto (sustancia), olsalazina, producto, olsalacina (sustancia), olsalazina (sustancia), olsalazina |