II. Indications
- Nausea or Vomiting
-
Motion Sickness or Vertigo
- Other agents are preferred (e.g. Dimenhydrinate)
III. Mechanism
IV. Contraindications
- Do not use under age 2 years
V. Adverse Effects
- Excessive sedation
- Respiratory Depression
- Apnea and death have occurred in children
VI. Precautions
- Long plasma half-life (observe prior to discharge)
- Lowers Seizure threshold
- Avoid use in children (absolutely contraindicated <2yo)
VII. Dosing
- Precautions: IV dosing used but not FDA labeled
- Adults: 12.5 to 25 mg PO/IM/PR q4-6 hours
- Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours
- Maximum: 25 mg per dose
VIII. Efficacy
- Less effective Antiemetic than Prochlorperazine (Compazine) in ER patients
- Sedation may delay Emergency Department discharge
IX. References
- Johnson (1993) Harriet Lane, Mosby, p. 521
- (2002) Tarascon Pocket Pharmacopoeia, p. 67
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| Promethazine DM syrup | #120 ml for $4.00 | $0.03 each |
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| Promethazine (on 6/18/2017 at Walmart.com) | ||
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| Promethazine plain syrup (on 6/18/2017 at Walmart.com) | ||
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| promethazine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PROMETHAZINE 12.5 MG SUPPOS | Generic | $7.67 each |
| PROMETHAZINE 12.5 MG TABLET | Generic | $0.09 each |
| PROMETHAZINE 25 MG SUPPOSITORY | Generic | $7.23 each |
| PROMETHAZINE 25 MG TABLET | Generic | $0.06 each |
| PROMETHAZINE 25 MG/ML AMPUL | Generic | $1.31 per ml |
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| PROMETHAZINE 50 MG SUPPOSITORY | Generic | $31.00 each |
| PROMETHAZINE 50 MG TABLET | Generic | $0.18 each |
| PROMETHAZINE 6.25 MG/5 ML SYRP | Generic | $0.02 per ml |
| PROMETHAZINE VC SYRUP | Generic | $0.21 per ml |
| PROMETHAZINE VC-CODEINE SYRUP | Generic | $0.39 per ml |
| PROMETHAZINE-CODEINE SYRUP | Generic | $0.03 per ml |
| PROMETHAZINE-DM SOLUTION | Generic | $0.01 per ml |
| PROMETHAZINE-DM SYRUP | Generic | $0.02 per ml |
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Ontology: Promethazine (C0033405)
| Definition (CHV) | a drug used to treat allergy symptoms |
| Definition (CHV) | a drug used to treat allergy symptoms |
| Definition (NCI) | A phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities. |
| Definition (MSH) | A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D011398 |
| SnomedCT | 256051006, 322154000, 372871004, 8372007 |
| LNC | LP15006-7, MTHU001492 |
| English | Promethazine, 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, Promethazine [nausea], Promethazine [nausea] [see c8i..], Proazamine, Prometazin, Promethazine [Chemical/Ingredient], prometazin, Promethazine [nausea] [see c8i..] (product), promethazine, PROMETHAZINE, Diprazinum, Promethazine product, Promethazine (product), Promethazine (substance), Promethazine [dup] (substance), Promethazine [nausea] [see c8i..] (substance) |
| Swedish | Prometazin |
| Czech | promethazin |
| Finnish | Prometatsiini |
| Russian | PROZAMIN, PROMETAZIN, TIAZINAMII, METILPROMETAZIN, МЕТИЛПРОМЕТАЗИН, ПРОЗАМИН, ПРОМЕТАЗИН, ТИАЗИНАМИЙ |
| Japanese | ヒベルナ, メチレンジサルチル酸プロメタジン, プロザミン, プロメタジン塩酸塩, ピレチア, フェネルガン, 塩酸プロメタジン, イソプロメタジン, プロメタジン |
| Spanish | prometazina (sustancia), prometazina [náuseas] [ver c8i..] (producto), prometazina [náuseas] [ver c8i..], Fenergan, prometacina (sustancia), prometacina, prometazina (producto), prometazina, Proazamina, Prometazina |
| Polish | Prometazyna, Difergan, Fenergan |
| Portuguese | Fenergan, Proazamina, Prometazina |
| French | Prométhazine |
| German | Proazamin, Promethazin |
| Italian | Prometazina |
Ontology: Phenergan (C0591971)
| Definition (CHV) | brand name of an allergy medicine |
| Definition (CHV) | brand name of an allergy medicine |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D011398 |
| English | Phenargan, phenergan, phenergan [brand name], Phenergan |
