II. Indications
- Nausea or Vomiting
-
Motion Sickness or Vertigo
- Other agents are preferred (e.g. Dimenhydrinate)
III. Mechanism
IV. Contraindications
- Do not use under age 2 years
V. Adverse Effects
- Excessive sedation
- Respiratory Depression
- Apnea and death have occurred in children
VI. Precautions
VII. Dosing
- Precautions: IV dosing used but not FDA labeled
- Adults: 12.5 to 25 mg PO/IM/PR q4-6 hours
- Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours
- Maximum: 25 mg per dose
VIII. Efficacy
- Less effective Antiemetic than Prochlorperazine (Compazine) in ER patients
- Sedation may delay Emergency Department discharge
IX. References
- Johnson (1993) Harriet Lane, Mosby, p. 521
- (2002) Tarascon Pocket Pharmacopoeia, p. 67
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