Mineral Oil

Aka: Mineral Oil, Kondremul, Mineral Oil Enema

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II. Indications

  1. Chronic Constipation

III. Contraindications

  1. Risk of Aspiration Pneumonia (lipoid Pneumonia)
  2. Malabsorption
  3. Age < 12 months

IV. Mechanism

  1. Lubricant Laxative
    1. Mineral Oil coats the bowel and stool with a waterproof film
    2. Decreases bowel absorption of water

V. Precautions

  1. Aspiration risk

VI. Dosing

  1. General
    1. Give chilled in juice to maximize tolerability
    2. Coadminister Multivitamin daily if used chronically
  2. Child Dose (over 18 months of age)
    1. Oral Dose
      1. Give 1 to 3 ml/kg/day divided daily to twice daily
      2. Used in maintenance of bowel regimen
      3. Maximum: 90 ml/day
    2. Rectal Dose (Mineral Oil Enema)
      1. Age 2 to 11 years: Give 30 to 60 ml per Rectum once daily
      2. Age 12 to 18 years: Give 60 to 150 ml per Rectum once daily
    3. Disimpaction
      1. Give 15-30 ml per age in years up to 240 ml/day
      2. May repeat daily for 3-4 days
  3. Adult Dose (or age > 12 years)
    1. Low Dose
      1. Take 5 to 45 ml orally in the evening
    2. High Dose
      1. Take 30 to 90 ml as needed

VII. Pharmacokinetics

  1. Onset of action
    1. Oral: 6 to 8 hours
    2. Rectal: 2 to 15 minutes

VIII. Adverse Effects

  1. Abdominal cramping
  2. Lipoid pneumonitis if aspirated
    1. Avoid bedtime dosing
  3. Anal irritation and leakage
  4. Vitamin malabsorption

IX. Resources

  1. Mineral Oil
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe39836b-97db-4472-a1d9-582152443dfa

X. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 94
  2. (2023) Management of Constipation, Presc Lett, #390108

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Cost: Medications

mineral oil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MINERAL OIL Generic OTC $0.01 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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