II. Indications

III. Mechanism

  1. Poorly absorbed, hyperosmolar agents

IV. Medications

  1. Sorbitol 70% Oral Solution
  2. Sorbitol 25 to 30% Enema

V. Dosing

  1. General
    1. Sweet taste
    2. Onset of action in 24 to 48 hours
  2. Adult (and age >12 years)
    1. Oral: Take 30 to 45 ml Sorbitol 70% orally daily
    2. Rectal: 120 ml per Rectum of Sorbitol 25% Enema
  3. Child (age 1 to 11 years)
    1. Oral: Give 1 ml/kg/day Sorbitol 70% orally once to twice daily
    2. Rectal: Give 30 to 60 ml per Rectum of Sorbitol 25% Enema

VI. Pharmacokinetics

  1. Poorly-absorbed sugar, similar to lactose (and may be used in Renal Failure)
  2. Onset of action in 24 to 48 hours

VII. Adverse Effects

  1. Flatulence
  2. Abdominal cramping

VIII. Safety

  1. Pregnancy Category C
  2. Unklnown safety in Lactation

X. References

  1. (2023) Management of Constipation, Presc Lett, #390108

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Ontology: Sorbitol (C0037688)

Definition (NCI) A sugar alcohol found in fruits and plants with diuretic, laxative and cathartic property. Unabsorbed sorbitol retains water in the large intestine through osmotic pressure thereby stimulating peristalsis of the intestine and exerting its diuretic, laxative and cathartic effect. In addition, sorbitol has one-third fewer calories and 60 % the sweetening activity of sucrose and is used as a sugar replacement in diabetes.
Definition (MSH) A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
Definition (CSP) six-carbon sugar alcohol with about half the sweetness of sucrose; occurs naturally and is also produced synthetically from glucose.
Concepts Pharmacologic Substance (T121) , Carbohydrate (T118)
MSH D013012
SnomedCT 89939002, 19839007, 412513004
LNC LP62208-1
English Glucitol, Sorbitol, D-Glucitol, D glucitol, Sorbitol agent, Sorbitol [Chemical/Ingredient], d-glucitol, sorbitol, SORBITOL, Sorbitol agent (substance), Sorbitol preparation, Sorbitol (substance), Sorbitol preparation (substance), Sorbitol (product)
Swedish Sorbitol
Czech sorbitol, sorbit
Finnish Sorbitoli
French D-Glucitol, Sorbitol
Russian GLIUTSIT, SORBIT, ГЛЮЦИТ, СОРБИТ
Italian Glucitolo, Sorbitolo
Croatian Not Translated[Sorbitol]
Polish Glucitol, Sorbitol, Sorbit
Japanese グルシトール, グルシット, ソルビット, ソルビトール
Spanish preparado de sorbitol (sustancia), preparado de sorbitol, sorbitol (sustancia), sorbitol, sorbitol (producto), Glucitol, Sorbitol
Portuguese Glicitol, Glucitol, Sorbitol
German Glucitol, Glucit, Sorbitol, Sorbit