II. Indications

III. Contraindications

  1. Giazo is FDA approved for male patients only

IV. Mechanism

  1. Diazo-Bonded 5-ASA product
    1. Oral agent converted to active 5-ASA (Mesalamine) by Bacteria within the colon

V. Dosing: Adult (and age>5 years)

  1. Colazal
    1. Start 2.25 g orally three times daily for 8 to 12 weeks
    2. Next 3 to 6 g/day divided three times daily
  2. Giazo (only male patients)
    1. Start 3.3 g orally twice daily for 8 weeks

VI. Pharmacokinetics

  1. Minimal absorption

VII. Efficacy

  1. Similar, but better tolerated (less Diarrhea) than Olsalazine

VIII. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

X. References

  1. (2022) Treatment of Mild to Moderate Ulcerative Colitis, Presc Lett, #350406
  2. (2023) Drugs for Inflammatory Bowel Disease, Med Lett Drug Ther 65: 105-12

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Related Studies

Cost: Medications

balsalazide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
BALSALAZIDE DISODIUM 750 MG CP Generic $0.42 each