II. Indications
III. Contraindications
- Giazo is FDA approved for male patients only
IV. Mechanism
- Diazo-Bonded 5-ASA product
- Oral agent converted to active 5-ASA (Mesalamine) by Bacteria within the colon
V. Dosing: Adult (and age>5 years)
- Colazal
- Start 2.25 g orally three times daily for 8 to 12 weeks
- Next 3 to 6 g/day divided three times daily
- Giazo (only male patients)
- Start 3.3 g orally twice daily for 8 weeks
VI. Pharmacokinetics
- Minimal absorption
VII. Efficacy
- Similar, but better tolerated (less Diarrhea) than Olsalazine
VIII. Safety
- Pregnancy Category B
- Unknown safety in Lactation
IX. Resources
- Balsalazide-Colazal (DailyMed)
X. References
- (2022) Treatment of Mild to Moderate Ulcerative Colitis, Presc Lett, #350406
- (2023) Drugs for Inflammatory Bowel Disease, Med Lett Drug Ther 65: 105-12
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Related Studies
balsalazide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
BALSALAZIDE DISODIUM 750 MG CP | Generic | $0.42 each |
Ontology: Balsalazide disodium (C0595398)
Definition (NCI) | The disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Mesalazine acts locally on the mucosa of the colon where it diminishes inflammation by blocking the production of arachidonic acid metabolites, including leukotrienes, prostaglandins and hydroxyeicosatetraenoic acids, and other inflammatory agents. Balsalazide disodium is used to treat chronic inflammatory bowel disease. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C038637 |
SnomedCT | 391811002, 317447005, 363630002 |
English | Benzoic Acid, 5-((1E)-(4-(((2-Carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxy-, Disodium Salt, Balsalazide disodium - chemical (substance), balsalazide disodium (medication), Balsalazide disodium - chemical, Balsalazide disodium (substance), balsalazide disodium for ulcerative colitis (medication), balsalazide disodium for ulcerative colitis, BALSALAZIDE DISODIUM, Balsalazide disodium product (product), Balsalazide disodium (product), Balsalazide disodium product, Balsalazide disodium, Balsalazide disodium product (substance), balsalazide disodium, Balsalazide Disodium |
Spanish | balsalazida disódica - sustancia química (sustancia), balsalazida disódica (sustancia), balsalazida disódica, balsalazida disódica - sustancia química, balsalazida disódica (producto), producto con balsalazida disódica (producto), producto con balsalazida disódica |