II. Indications
- Peptic Ulcer Disease
- Esophageal Reflux disease
- Gastritis
- Allergic Reaction (adjunct)
III. Mechanism
- See H2 Blocker
IV. Dosing
- Adult
- Removed from U.S. market in 2020 due to NDMA contaminant (see adverse effects below)
- Bolus IV Dosing: 50 mg IV every 6 to 8 hours
- Continuous IV Dosing: 6.25 mg/hour IV
- Oral Dosing: 150 mg orally twice daily
- Child (15 mg/ml oral syrup)
- Removed from U.S. market in 2020 due to NDMA contaminant (see adverse effects below)
- Age <16 years old
- Dose: 5-10 mg/kg/day (max 300 mg) divided every 12 hours
- Adult dosing for over age 16 years old
- Dose: 150 mg twice daily
-
Creatinine Clearance <50 ml/min
- Give at half dose
V. Efficacy
- See H2 Blocker
VI. Adverse Effects
- See H2 Blocker
- Ranitidine (Zantac) was removed from U.S. market in 2020 due to NDMA contaminant
- NDMA has been associated with several cancers
- NDMA was found both as a manufacturing contaminant
- NDMA also appears to form in vivo with Ranitidine use
- Resulted in the complete withdrawal of Ranitidine from U.S. market
- In-vivo NDMA formation does not appear to occur with other H2 Blockers
- FDA Recall Information
- IV Ranitidine associated adverse effects
- Alanine Aminotransferase (ALT) increase
- Associated with prolonged (>5 days), high dose IV use
- Bradycardia
- Associated with rapid IV administration
- Alanine Aminotransferase (ALT) increase
VII. Drug Interactions
-
Antacids
- Take Cimetidine at least 1-2 hours before or after Antacid medications
- Decreases absorption of other medications
-
Warfarin
- May affect drug levels
VIII. Safety
- Pregnancy Category B
- Unknown safety in Lactation
IX. Resources
X. References
- (2012) Presc Lett, 19(7): 38
- Baird (2015) Am Fam Physician 92(8): 705-14 [PubMed]
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Definition (CHV) | a kind of antiacid drug |
Definition (CHV) | a kind of antiacid drug |
Definition (NCI) | A member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked. |
Definition (MSH) | A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. |
Definition (CSP) | N-2-(5-dimethylamino)methyl-2- furanylmethyl thioethyl-N'-methyl-2-nitro-1,1 -ethenediamine; cimetidine analog; H2 histamine receptor antagonist used to treat gastric ulcers. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D011899 |
SnomedCT | 372755005, 48174005 |
LNC | LP17253-3, MTHU005040 |
English | Ranitidin, Ranitidine, N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine, 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-, N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine, ranitidine (medication), histamine-2 receptor antagonists ranitidine, RANITIDINE, Ranitidine [Chemical/Ingredient], ranitidin, ranitidine, Ranitidine (product), Ranitidine (substance) |
Swedish | Ranitidin |
Czech | ranitidin |
Finnish | Ranitidiini |
Russian | RANITIDIN, РАНИТИДИН |
Japanese | ラニチジン |
Croatian | RANITIDIN |
Polish | Ranitydyna |
Norwegian | Ranitidin |
Spanish | ranitidina (producto), ranitidina (sustancia), ranitidina, Ranitidina |
French | Ranitidine |
German | Ranitidin |
Italian | Ranitidina |
Portuguese | Ranitidina |
Ontology: Zantac (C0592278)
Definition (CHV) | brand name of an heartburn medication |
Definition (CHV) | brand name of an heartburn medication |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D011899 |
English | zantac, zantac [brand name], Zantac |