N-Nitrosodimethylamine

Aka: N-Nitrosodimethylamine, NMDA, Dimethylnitrosamine, N-nitrosodiethylamine, NDEA

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II. Background

  1. NMDA, NDEA are associated with several product recalls
    1. Angiotensin Receptor Blockers or ARBs (e.g. Valasartan) in 2018
      1. https://www.fda.gov/Drugs/DrugSafety/ucm613916.htm
      2. https://www.fda.gov/Safety/Recalls/ucm624593.htm
      3. https://www.fda.gov/Safety/Recalls/ucm625492.htm
    2. OTC Ranitidine in 2019
      1. https://www.fda.gov/drugs/drug-safety-and-availability/fda-updates-and-press-announcements-ndma-zantac-ranitidine

III. Adverse Effects: Carcinogenic Effects

  1. Unclear risk
  2. Low levels of NMDA are present in water, grilled meats, bacon, dairy products
  3. Overall risk appears to be low
    1. With Valsartan, cancer risk was thought to be 1 in 8000 patients taking it for 4-8 years at 320 mg/day

IV. Resources

  1. N-Nitrosodimethylamine (Wikipedia)
    1. https://en.wikipedia.org/wiki/N-Nitrosodimethylamine

V. References

  1. (2018) Presc Lett 25(9): 49
  2. (2018) Presc Lett 26(11): 62

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