II. Indications
- Emesis of central cause
III. Mechanism
- Centrally acting non-Phenothiazine Antiemetic
-
Dopamine 2 Antagonist
- Active at the ChemoreceptorTrigger Zone in the Medulla of the Brainstem
IV. Dosing
- Adults
- Dose: 300 mg orally or 200 mg IM every 6 to 8 hours
- Child (15 to 41 kg)
- Dose: 100-200 mg orally three to four times daily
- Child (<15 kg): Avoid
V. Safety
- Pregnancy Category C
- Unknown safety in Lactation
- Reduce dose in renal dysfunction and older patients
VI. Resources
- Trimethobenzamide (DailyMed)
VII. References
- Johnson (1993) Harriet Lane, Mosby, p. 521
- Hamilton (2020) Tarascon Pocket Pharmacopoeia