Prucalopride

Aka: Prucalopride, Motegrity

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II. Indications

  1. Chronic Idiopathic Constipation
  2. Constipation Dominant Irritable Bowel Syndrome

III. Contraindications

  1. Children
  2. Renal Failure
  3. Mechanical Bowel Obstruction

IV. Mechanism

  1. Selective Serotonin 4 Receptor Agonist (5HT4 Agonist)
    1. Prokinetic that stimulates colonic peristalsis

V. Dosing

  1. Take 2 mg orally once daily
  2. Decrease dose to 1 mg/day in eGFR <30 ml/min

VI. Adverse Effects

  1. Headache
  2. Nausea
  3. Diarrhea
  4. Abdominal Pain

VII. Safety

  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation

VIII. Resources

  1. Prucalopride (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bca1e4c6-4b2b-4876-8ab3-654629c4ff1b

IX. References

  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 98
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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