II. Indications

  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome

III. Contraindications

  1. Hypersensitivity to Proton Pump Inhibitors
  2. Severe liver disease
    1. Limit maximum dose to 30 mg/day in moderate liver Impairment

IV. Medications

  1. Dexlansoprazole (Dexilant) is the active L-Isomer of Lansoprazole (Prevacid)

V. Dosing

  1. Background
    1. Take regardless of timing of meal
    2. May open capsule and sprinkle on applesauce or water (may be given via NG tube)
    3. See Proton Pump Inhibitor for Discontinuation or Deprescribing
    4. Generic, but not OTC as of 2022
  2. Adults and age >=12 years
    1. Symptomatic Nonerosive Gastroesophageal Reflux
      1. Take 30 mg orally daily
    2. Erosive Esophagitis
      1. Take 60 mg orally daily for up to 8 weeks, then 30 mg orally daily for up to 6 months

VI. Pharmacokinetics

  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19 and CYP3A4

VII. Mechanism

VIII. Adverse Effects:

IX. Precautions

X. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

XI. Efficacy

XII. Drug Interactions

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

dexlansoprazole (on 2/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
DEXLANSOPRAZOLE DR 30 MG CAP Generic $7.29 each
DEXLANSOPRAZOLE DR 60 MG CAP Generic $7.09 each
dexilant (on 8/17/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DEXILANT DR 30 MG CAPSULE Generic $7.15 each
DEXILANT DR 60 MG CAPSULE Generic $7.22 each