Dexlansoprazole

Aka: Dexlansoprazole, Dexilant

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II. Indications

  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome

III. Contraindications

  1. Hypersensitivity to Proton Pump Inhibitors
  2. Severe liver disease
    1. Limit maximum dose to 30 mg/day in moderate liver Impairment

IV. Medications

  1. Dexlansoprazole (Dexilant) is the active L-Isomer of Lansoprazole (Prevacid)

V. Dosing

  1. Background
    1. Take regardless of timing of meal
    2. May open capsule and sprinkle on applesauce or water (may be given via NG tube)
    3. See Proton Pump Inhibitor for Discontinuation or Deprescribing
    4. Generic, but not OTC as of 2022
  2. Adults and age >=12 years
    1. Symptomatic Nonerosive Gastroesophageal Reflux
      1. Take 30 mg orally daily
    2. Erosive Esophagitis
      1. Take 60 mg orally daily for up to 8 weeks, then 30 mg orally daily for up to 6 months

VI. Pharmacokinetics

  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19 and CYP3A4

VII. Mechanism

  1. See Proton Pump Inhibitor

VIII. Adverse Effects:

  1. See Proton Pump Inhibitor

IX. Precautions

  1. See Proton Pump Inhibitor

X. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

XI. Efficacy

  1. See Proton Pump Inhibitor

XII. Drug Interactions

  1. See Proton Pump Inhibitor

XIII. Resources

  1. Dexlansoprazole (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9819f033-3bbe-442e-8e92-45fec77b237d

XIV. References

  1. (2022) Comparison of Proton Pump Inhibitors, Presc Lett, #380327
  2. (2012) Prescr Lett 19(3): 14 [PubMed]
  3. (2013) Prescr Lett 20(5): 30 [PubMed]
  4. (2001) Med Lett Drugs Ther 43(1103):36-7 [PubMed]
  5. Ament (2012) Am Fam Physician 86(1): 66-70 [PubMed]
  6. Vanderhoff (2002) Am Fam Physician 66(2):273-80 [PubMed]

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Related Studies

Cost: Medications

dexlansoprazole (on 2/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
DEXLANSOPRAZOLE DR 30 MG CAP Generic $7.29 each
DEXLANSOPRAZOLE DR 60 MG CAP Generic $7.09 each
dexilant (on 8/17/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DEXILANT DR 30 MG CAPSULE Generic $7.15 each
DEXILANT DR 60 MG CAPSULE Generic $7.22 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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