II. Precautions: Pharmacogenetics
- See Pharmacogenetics
- Poor metabolizers (2-15%, 20% in asians)
- Clopidogrel with reduced conversion to active form (higher risk for stent closure)
- Amitriptyline and Nortriptyline risk of toxicity (reduce starting dose by 50%)
- Citalopram, Escitalopram, Sertraline risk of toxicity (reduce starting dose by 50%)
- Omeprazole blood concentrations are 5x higher (increased efficacy)
- Ultra-Metabolizers (18% of Swedes and 18% of Ethiopians)
- Citalopram, Escitalopram, Sertraline with reduced effect (consider alternative agents)
- Omeprazole blood concentrations are 40% lower
- Reference
III. Interactions: Metabolized by CYP2C19 (Substrates)
- Neuropsychiatric drugs
- Cardiopulmonary Drugs
- Antibiotics
- Miscellaneous
- Lansoprazole
- Pentamidine
- Felbamate
- Omeprazole (Prilosec)
IV. Interactions: Inhibitor of CYP2C19
- Neuropsychiatric drugs
- Antibiotics
- Miscellaneous
V. Interactions: Inducer of CYP2C19
- Neuropsychiatric Drugs
- Antibiotics
Images: Related links to external sites (from Bing)
Related Studies
Definition (NCI) | Cytochrome P450 2C19 (490 aa, ~56 kDa) is encoded by the human CYP2C19 gene. This protein is involved in steroid, terpenoid and drug metabolism. |
Concepts | Amino Acid, Peptide, or Protein (T116) , Enzyme (T126) |
MSH | C045793 |
SnomedCT | 423556000 |
English | cytochrome P450 CYP2C(mp), cytochrome P450 2C19, human, Cytochrome p450 CYP2C19 enzyme (substance), Cytochrome p450 CYP2C19 enzyme, CYP2C19, cyp2c19, Mephenytoin 4-Hydroxylase, Cytochrome P450-11A, (S)- Limonene 6-Monooxygenase, EC 1.14.13.48, EC 1.14.13.49, (S)- Limonene 7-Monooxygenase, EC 1.14.13.-, (R)- Limonene 6-Monooxygenase, Cytochrome P450-254C, EC 1.14.13.80, Cytochrome P450 2C19, Cytochrome P450, Family 2, Subfamily C, Polypeptide 19, cytochrome P450 CYP2C19 (human), CYP2C(mp) protein, human, CYP2C19, human, CYPIIC19, human, P4502C19, human, cytochrome p-450 mephenytoin 4-hydroxylase, human, mephenytoin hydroxylase, human, propranolol 4-hydroxylase, human, (S)-mephenytoin-4'-hydroxylase, human, CYP2C19 protein, human, Flavoprotein-Linked Monooxygenase, CYPIIC17, CYPIIC19, P450-11A, P450-254C, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19, Mephenytoin 4'-Hydroxylase, Mephenytoin 4-Prime-Hydroxylase, Microsomal Monooxygenase, Xenobiotic Monooxygenase |
Spanish | enzima CYP2C19 del citocromo p450, enzima CYP2C19 del citocromo p450 (sustancia), CYP2C19 |