II. Class
- Long Acting Benzodiazepine
III. Dosing
-
Anxiety Disorder
- Adult: 5 to 10 mg orally 2 to 4 times daily (up to 20 to 25 mg per dose)
- Elderly: 5 mg orally 2 to 4 times daily
- Child (over age 6 years): 5 mg orally 2 to 4 times daily (up to 10 mg orally 2 to 3 times daily)
-
Alcohol Withdrawal
- See Alcohol Withdrawal
- Start 25 to 50 mg orally every 3 to 4 hours as needed
- May increase doses to 50-100 mg
- Repeat dosing every 3-4 hours up to 300 mg per day
IV. Safety
- Pregnancy Category X
- Avoid in Lactation
- Schedule IV Controlled Substance
V. Pharmacokinetics
- Onset: 6 hours
- Half Life: 7-48 hours (up to 100 hours)
- Chlordiazepoxide has the longest half life of any Benzodiazepine
VI. Metabolism
VII. Resources
- Chlordiazepoxide Capsule (DailyMed)
VIII. References
- (2019) Med Lett Drugs Ther 61(1578): 121-6
- (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| chlordiazepoxide (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CHLORDIAZEPOXIDE 10 MG CAPSULE | Generic | $0.13 each |
| CHLORDIAZEPOXIDE 25 MG CAPSULE | Generic | $0.16 each |
| CHLORDIAZEPOXIDE 5 MG CAPSULE | Generic | $0.19 each |
| CHLORDIAZEPOXIDE-CLIDINIUM CAP | Generic | $0.44 each |