Cytochrome P-450 1A2 Isoenzyme

Aka: Cytochrome P-450 1A2 Isoenzyme, CYP1A2, CYP1A2 Inducer, CYP1A2 Inhibitor, CYP1A2 Substrate

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II. Interactions: Metabolized by CYP1A2 (Substrates)

  1. Neuropsychiatric drugs
    1. Amitriptyline (Elavil)
    2. Clomipramine (Anafranil)
    3. Imipramine (Tofranil)
    4. Clozapine (Clozaril)
    5. Tacrine (Cognex)
  2. Cardiopulmonary Drugs
    1. Propranolol (Inderal)
    2. Theophylline
  3. Miscellaneous
    1. Acetaminophen (Tylenol)
    2. Caffeine
    3. Warfarin (Coumadin)

III. Interactions: Inhibitor of CYP1A2

  1. Neuropsychiatric Drugs
    1. Fluvoxamine (Luvox)
    2. Tacrine (Cognex)
  2. Cardiopulmonary Drugs
    1. Verapamil
    2. Diltiazem
    3. Amiodarone (inhibitor)
  3. Antibiotics
    1. Enoxacin: Inhibitor
    2. Ciprofloxacin: Inhibitor
    3. Norfloxacin: Inhibitor
  4. Miscellaneous Drugs
    1. Grapefruit juice
    2. Cimetidine
    3. Ticlopidine

IV. Interactions: Inducers of CYP1A2

  1. Neuropsychiatric drugs
    1. Phenobarbital
    2. Phenytoin
  2. Antibiotics
    1. Rifampin
  3. Miscellaneous
    1. Charcoal broiled beef
    2. Tobacco exposure (e.g. Cigarette smoke)
    3. Cruciferous vegetables
    4. Omeprazole (Prilosec)

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