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Ontology:
Amitriptyline
(C0002600)
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Definition (NCI_NCI-GLOSS)
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A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant.
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Definition (NCI)
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A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.
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Definition (MSH)
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Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
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Definition (CSP)
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tricyclic antidepressant with anticholinergic and sedative properties; it appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters; it also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D000639
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| SnomedCT |
372726002, 40589005 |
| LNC |
LP14983-8, MTHU004907 |
| English |
Amitriptyline, amitriptyline, 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, Amitriptyline [Chemical/Ingredient], AMITRIPTYLINE, Amitriptyline (product), Amitriptyline (substance) |
| Swedish |
Amitriptylin
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| Czech |
amitriptylin
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| Finnish |
Amitriptyliini
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| Russian |
TRIPTIZOL, TEPERIN, AMITRIPTILIN, АМИТРИПТИЛИН, ТЕПЕРИН, ТРИПТИЗОЛ |
| Japanese |
アミトリプチリン, 塩酸アミトリプチリン |
| Croatian |
AMITRIPTILIN
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| Polish |
Amitryptylina
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| Spanish |
amitriptilina (producto), amitriptilina (sustancia), amitriptilina, Amitriptilina |
| French |
Amitriptyline
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| German |
Amitriptylin
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| Italian |
Amitriptilina
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| Portuguese |
Amitriptilina
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Ontology:
Elavil
(C0087119)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D000639
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| English |
Cahill May Roberts Brand of Amitriptyline Embonate, Cahill May Roberts Brand of Amitriptyline Hydrochloride, DDSA Brand of Amitriptyline Hydrochloride, Merck Sharp & Dohme Brand of Amitriptyline Embonate, Merck Sharp & Dohme Brand of Amitriptyline Hydrochloride, Tryptanol, Zeneca Brand of Amitriptyline Hydrochloride, Elavil, Tryptizol |
