II. Mechanism
III. Indication
- Insomnia
- Consider for early awakening in middle of night
IV. Pharmacokinetics
V. Dosing
- Start: 5-10 mg orally at bedtime
- Elderly: 5 mg orally at bedtime
- Maximum: 20 mg orally at bedtime
VI. Adverse Effects
- See Nonbenzodiazepine Hypnotic Agent for common effects
- Altered color Perception
VII. Advantages
- See Nonbenzodiazepine Hypnotic Agent
- Effective in middle of night awakening
- Can take mid-way through sleep period
VIII. Resources
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Related Studies
zaleplon (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
ZALEPLON 10 MG CAPSULE | Generic | $0.16 each |
ZALEPLON 5 MG CAPSULE | Generic | $0.18 each |
Ontology: zaleplon (C0251504)
Definition (NCI) | A nonbenzodiazepine from the pyrazolopyrimidine class with hypnotic, sedative, anxiolytic, and muscle relaxant properties. Zaleplon interacts with the gamma-aminobutyric acid (GABA) -A receptor, thereby affecting the chloride channel ionophore complex and potentiating the inhibitory effects of GABA. In addition, zaleplon binds selectively to the brain omega-1 receptor situated on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C085665 |
SnomedCT | 321187004, 116104009, 387012004 |
LNC | LP30650-3, MTHU015092 |
English | Acetamide, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethyl-, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide, zaleplon, zaleplon (medication), ZALEPLON, zaleplon [Chemical/Ingredient], Zaleplon (product), Zaleplon (substance), Zaleplon |
Spanish | zaleplón (producto), zaleplón (sustancia), zaleplón |
Ontology: Sonata (C0876170)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C085665 |
English | Sonata, sonata, Lundbeck brand of zaleplon, Wyeth brand of zaleplon, Zelepion, AHP brand of zaleplon |