III. Background

  1. Released in 2021 in U.S.

IV. Contraindications

  1. Bipolar Disorder
    1. Risk of provoking a manic episode
  2. Concurrent use of Monoamine Oxidase Inhibitor
  3. Pregnancy
    1. Animal studies suggest fetal and maternal toxicity

V. Mechanism

  1. Selective Norepinephrine Reuptake Inhibitor (SNRI)
  2. Morpholine Derivative

VI. Efficacy: Attention Deficit Disorder

  1. Marginal efficacy at best (that may not be detected clinically)

VII. Dosing

  1. Start: 100 mg orally daily

VIII. Advantages

  1. Once daily dosing
  2. No abuse potential (similar in this regard to the lower cost Atomoxetine)

IX. Disadvantages

  1. Low efficacy
  2. Expensive: $300/month (3x the cost of generic Atomoxetine)

X. Adverse Effects

  1. Suicidal Ideation
  2. Increased Heart Rate or Sinus Tachycardia (20-30% of patients)
  3. Sleep and Constitutional Effects
    1. Insomnia (23% of patients)
    2. Somnolence (16% of children)
    3. Fatigue (6% of children)
  4. Gastrointestinal Effects
    1. Decreased Appetite (7% of children, 10% of adults)
    2. Nausea or Vomiting (4-5% of children, 12% of adults)
    3. Dry Mouth (10% of adults)
    4. Constipation (6% of adults)
  5. Neurologic Effects
    1. Headache (17% of adults)

XII. References

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

qelbree (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
QELBREE ER 100 MG CAPSULE $10.14 each
QELBREE ER 150 MG CAPSULE $10.11 each
QELBREE ER 200 MG CAPSULE $10.13 each

Ontology: Viloxazine (C0042665)

Definition (MSH) A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014745
SnomedCT 349857003, 420070007
English Viloxazine, Morpholine, 2-((2-ethoxyphenoxy)methyl)-, VILOXAZINE, Viloxazine [Chemical/Ingredient], viloxazine, Viloxazine (product), Viloxazine (substance)
Spanish viloxazina (sustancia), viloxazina (producto), viloxazina, Viloxazina
Swedish Viloxazine
Czech viloxazin
Finnish Viloksatsiini
Russian VILOKSAZIN, ВИЛОКСАЗИН
Japanese ビロキサジン
Polish Wiloksazyna
French Viloxazine
German Viloxazin
Italian Viloxazina
Portuguese Viloxazina