II. Indications
III. Background
- Released in 2021 in U.S.
IV. Contraindications
-
Bipolar Disorder
- Risk of provoking a manic episode
- Concurrent use of Monoamine Oxidase Inhibitor
- Pregnancy
- Animal studies suggest fetal and maternal toxicity
V. Mechanism
- Selective Norepinephrine Reuptake Inhibitor (SNRI)
- Morpholine Derivative
VI. Efficacy: Attention Deficit Disorder
- Marginal efficacy at best (that may not be detected clinically)
VII. Dosing
- Start: 100 mg orally daily
VIII. Advantages
- Once daily dosing
- No abuse potential (similar in this regard to the lower cost Atomoxetine)
IX. Disadvantages
- Low efficacy
- Expensive: $300/month (3x the cost of generic Atomoxetine)
X. Adverse Effects
- Suicidal Ideation
- Increased Heart Rate or Sinus Tachycardia (20-30% of patients)
-
Sleep and Constitutional Effects
- Insomnia (23% of patients)
- Somnolence (16% of children)
- Fatigue (6% of children)
- Gastrointestinal Effects
- Decreased Appetite (7% of children, 10% of adults)
- Nausea or Vomiting (4-5% of children, 12% of adults)
- Dry Mouth (10% of adults)
- Constipation (6% of adults)
- Neurologic Effects
- Headache (17% of adults)
XI. Resources
XII. References
- (2021) Presc Lett 28(9): 54
- Goodell (2023) Am Fam Physician 107(3): 309-10 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
qelbree (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
QELBREE ER 100 MG CAPSULE | $10.14 each | |
QELBREE ER 150 MG CAPSULE | $10.11 each | |
QELBREE ER 200 MG CAPSULE | $10.13 each |
Ontology: Viloxazine (C0042665)
Definition (MSH) | A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D014745 |
SnomedCT | 349857003, 420070007 |
English | Viloxazine, Morpholine, 2-((2-ethoxyphenoxy)methyl)-, VILOXAZINE, Viloxazine [Chemical/Ingredient], viloxazine, Viloxazine (product), Viloxazine (substance) |
Spanish | viloxazina (sustancia), viloxazina (producto), viloxazina, Viloxazina |
Swedish | Viloxazine |
Czech | viloxazin |
Finnish | Viloksatsiini |
Russian | VILOKSAZIN, ВИЛОКСАЗИН |
Japanese | ビロキサジン |
Polish | Wiloksazyna |
French | Viloxazine |
German | Viloxazin |
Italian | Viloxazina |
Portuguese | Viloxazina |