II. Indication
III. Class
- Long acting Benzodiazepine
IV. Pharmacokinetics
- Peak plasma concentration: 1-3 hours after oral dose
- Half Life: 14 hours
V. Dosing
- Dose: 20 to 40 mg PO tid to qid or 80 mg PO qhs
- Maximum Daily Dose: 160 mg
VI. Equivalent Dosing (for Benzodiazepine Withdrawal)
- Valium = Halazepam Dose x0.25
- Phenobarbital = Halazepam Dose x0.75
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Definition (NCI) | A synthetic benzodiazepine derivative with anxiolytic property. Halazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic, and hypothalamic regions of the central nervous system (CNS). This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C010175 |
SnomedCT | 63545000, 371367008 |
LNC | LP18083-3, MTHU003364 |
English | 7-chloro-1,3-dihydro-5-phenyl-1- (2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one, halazepam, halazepam (medication), halazepam [Chemical/Ingredient], Halazepam, Halazepam (substance), Halazepam product (product), Halazepam product, HALAZEPAM |
Spanish | halazepam, halazepam (producto), halazepam, producto (producto), halazepam, producto, halacepam (sustancia), halacepam |
Ontology: Paxipam (C0722503)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
English | Paxipam |