II. Class
- Medium acting Benzodiazepine
III. Indication
-
Insomnia
- Short-term use only (up to 12 weeks)
IV. Dosing
- Adult: 1 to 2 mg orally at bedtime
- Elderly: 0.5 to 1 mg orally at bedtime
V. Safety
- Pregnancy Category X
- Avoid in Lactation
- Schedule IV Controlled Substance
VI. Pharmacokinetics
- Onset: 20 minutes
- Duration: 6-8 hours
- Half-Life: 10-24 hours
- Metabolites are minimally active
VII. Drug Interactions
- Strong CYP3A4 Inhibitors (e.g. Ketoconazole, Itraconazole)
- Avoid Estazolam with these agents
VIII. Adverse Effects
- See Benzodiazepine
IX. Resources
X. References
- (2019) Med Lett Drugs Ther 61(1578): 121-6
- (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
estazolam (on 9/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
ESTAZOLAM 2 MG TABLET | Generic | $1.37 each |
Ontology: Estazolam (C0014892)
Definition (NCI) | A triazolo-benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system (CNS). This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability. |
Definition (MSH) | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D004949 |
SnomedCT | 96235001, 371364001 |
LNC | LP16131-2, MTHU004627 |
English | Estazolam, 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-, 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine, sedatives estazolam, estazolam (medication), estazolam, ESTAZOLAM, Estazolam [Chemical/Ingredient], Estazolam (substance), Estazolam product (product), Estazolam product |
Swedish | Estazolam |
Czech | estazolam |
Finnish | Estatsolaami |
Russian | ESTAZOLAM, ЭСТАЗОЛАМ |
Japanese | エスタゾラム |
Spanish | estazolam, producto (producto), estazolam (producto), estazolam, producto, estazolam (sustancia), estazolam, Estazolam |
Polish | Estazolam |
French | Estazolam |
German | Estazolam |
Italian | Estazolam |
Portuguese | Estazolam |
Ontology: ProSom (C0722865)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D004949 |
English | Prosom, prosom, ProSom, Abbott Brand of Estazolam |