III. Contraindications (relative)

  1. Coronary Artery Disease
  2. Hypertension
  3. Other cardiovascular disease

IV. Mechanism

  1. Stimulant

V. Dosing: Adults

  1. ADHD: 100-300 mg PO qd (Not FDA approved)
  2. Narcolepsy: 200 mg qAM

VI. Dosing: Children Age >5 years

  1. ADHD: 50-100 mg PO qd (Not FDA approved)

VII. Efficacy: Narcolepsy

  1. May be slightly less effective then agents above
  2. Less addictive potential then agents above
  3. (1999) Med Lett Drugs Ther 41(1049):30-2 [PubMed]

VIII. Efficacy: ADHD

IX. Adverse Effects

X. References

  1. (2003) Lexi-Comp Drug Database for Pocket PC (7/9/03)

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Related Studies

Cost: Medications

modafinil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MODAFINIL 100 MG TABLET Generic $0.30 each
MODAFINIL 200 MG TABLET Generic $0.60 each
provigil (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PROVIGIL 200 MG TABLET Generic $0.60 each

Ontology: modafinil (C0066677)

Definition (NCI) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. (NCI04)
Definition (NCI_NCI-GLOSS) A drug that is being studied as a treatment for fatigue in patients with cancer. It belongs to the family of drugs called stimulants.
Definition (PDQ) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26661" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C048833
SnomedCT 116082007, 387004007
LNC LP66956-1, MTHU028053
English benzhydrylsulfinylacetamide, modafinil, modafinil (medication), MODAFINIL, modafinil [Chemical/Ingredient], 2-((diphenylmethyl)sulfinyl)acetamide, Modafinil, Modafinil (product), Modafinil (substance)
Spanish modafinilo, modafinilo (producto), modafinil, modafinilo (sustancia), modafinil (producto), modafinil (sustancia)

Ontology: Provigil (C0722882)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C048833
English Provigil, modafinil (Provigil), provigil, Cephalon brand of modafinil