II. Indications

  1. Anxiety Disorder
  2. Preanesthetic medication
  3. Status Epilepticus

III. See Also

IV. Class

  1. Medium Acting Benzodiazepine

V. Pharmacokinetics

  1. Half Life: 10-20 hours
  2. Onset: 2-3 minutes with IV dosing
  3. Duration: 12-24 hours

VI. Dosing: General

  1. Anxiety Disorder
    1. Dose: 0.5 to 2 mg IV, IM or orally every 6 to 8 hours as needed
    2. Maximum Daily Dose: 4 mg
  2. Status Epilepticus
    1. IV: 0.1 mg/kg IV (<2 mg/minute) up to 4 mg
    2. Rectal: 0.1 mg/kg up to 4 mg
    3. Avoid IM Lorazepam (unreliable in Status Epilepticus)
    4. May repeat once in 5-10 minutes
    5. Avoid more than 2 doses in children due to risk of respiratory depression

VII. Dosing: Equivalent (for Benzodiazepine Withdrawal)

  1. Valium = Dose x5.0
  2. Phenobarbital = Dose x15.0

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Related Studies

Cost: Medications

lorazepam (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
LORAZEPAM 0.5 MG TABLET Generic $0.04 each
LORAZEPAM 1 MG TABLET Generic $0.04 each
LORAZEPAM 2 MG TABLET Generic $0.07 each
LORAZEPAM 2 MG/ML ORAL CONCENT Generic $0.53 per ml
LORAZEPAM INTENSOL 2 MG/ML Generic $0.53 per ml
ativan (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ATIVAN 0.5 MG TABLET Generic $0.04 each
ATIVAN 1 MG TABLET Generic $0.04 each