II. Class
- Atypical Antipsychotic (Second Generation agent)
III. Indications
- Schizophrenia
- Bipolar Disorder
- Major Depression (adjunct in refractory cases)
IV. Advantages
- Lower weight gain than other second generation Antipsychotic agents
- Lower diabetes risk than other second generation Antipsychotic agents
V. Precautions
- Despite generic in 2015, price still approaches $800 per month
- Primary role remains as an Antipsychotic for Schizophrenia and Bipolar Disorder
- Only consider adjunctively in severe Major Depression refractory to other measures
VI. Drug Interactions
- Increase Antipsychotic levels (toxicity risk): Monitor for Aripiprazole toxicity
- Increase Antipsychotic levels (toxicity risk): Lower Aripiprazole dose to half
- Decrease Antipsychotic levels (lower efficacy)
VII. Efficacy: Depression
- Depression remits in 25% of patients by 6 weeks (effects may be seen by 1 week)
VIII. Adverse Effects
- Headache
- Restlessness or Agitation
- Insomnia
- Anxiety
- Extrapyramidal Side Effects in up to 17% of patients
- Nausea
- Constipation
- Fatigue or sedation
- Impulse control behaviors (rare)
- Behaviors seen with other Dopamine Agonists (e.g. Compulsive Gambling, hypersexuality, shopping, eating)
- Moore (2014) JAMA Intern Med 174(12):1930-3 [PubMed]
IX. Monitoring
- See Antipsychotic
X. Dosing: Schizophrenia or Bipolar Disorder
- Starting dose: 10-15 mg once daily
- Maximum dose: 30 mg/day
XI. Dosing: Major Depression (in refractory and atypical cases)
- Starting dose: 2-5 mg/day
- Maximum dose: 15 mg/day (up to 30 mg/day has been used)
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Related Studies
| aripiprazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ARIPIPRAZOLE 1 MG/ML SOLUTION | Generic | $1.09 per ml |
| ARIPIPRAZOLE 10 MG TABLET | Generic | $0.13 each |
| ARIPIPRAZOLE 15 MG TABLET | Generic | $0.14 each |
| ARIPIPRAZOLE 2 MG TABLET | Generic | $0.13 each |
| ARIPIPRAZOLE 20 MG TABLET | Generic | $0.26 each |
| ARIPIPRAZOLE 30 MG TABLET | Generic | $0.28 each |
| ARIPIPRAZOLE 5 MG TABLET | Generic | $0.15 each |
| abilify (on 12/15/2021 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ABILIFY 10 MG TABLET | Generic | $0.13 each |
| ABILIFY 15 MG TABLET | Generic | $0.14 each |
| ABILIFY 5 MG TABLET | Generic | $0.15 each |
| ABILIFY MAINTENA ER 300 MG SYR | $1,827.31 each | |
| ABILIFY MAINTENA ER 300 MG VL | $1,834.87 each | |
| ABILIFY MAINTENA ER 400 MG SYR | $2,444.19 each | |
| ABILIFY MAINTENA ER 400 MG VL | $2,445.84 each | |