Serotonin Antagonist and Reuptake Inhibitor

Aka: Serotonin Antagonist and Reuptake Inhibitor, SARI

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II. Mechanism

  1. Phenylpiperazine Antidepressant (Serzone prototype)
  2. Unrelated to Tricyclic Antidepressants
  3. Serotonin Antagonist and Reuptake Inhibitor (SARI)
    1. Blocks 5-HT-2 postsynaptic receptor

III. Medications

  1. Trazodone (Desyrel)
  2. Nefazodone (Serzone)
    1. Off U.S. market as of 2003 due to hepatotoxicity

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