II. Indications
III. Efficacy
- One year quit rate 25% (12% for Placebo)
- Best in obese heavy smokers and non-white patients
IV. Mechanism
- Rapidly absorbed via nasal mucosa
V. Preparations
- Available only by prescription in the United States
- Concentration 10 mg/ml and provides 0.5 mg/spray
- Each bottle contains 10 ml
VI. Dosing
- One dose is 1 spray each nostril (1 mg Nicotine)
- Start 1-2 doses per hour while awake for 8 weeks
- Do not exceed 5 doses per hour (or more than 40 doses per day)
- Taper over the next month
- Minimum recommended: 8 doses (8 mg) per day
- Maximum: 40 doses (40 mg) per day
- Do not use more than 6 months total
VII. Contraindications
- Same as Nicotine Patch
- Bronchospasm
VIII. Adverse Effects
- Nasal Irritation (90%): Rhinorrhea or sneezing
- Symptoms may be severe
- Often continues throughout course of use
- Throat irritation
- Nausea
- Watery eyes
- Cough
IX. Precautions
- Pregnancy Category D
- Greater abuse potential than Nicotine Patch or gum
X. References
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| nicotrol ns (on 1/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| NICOTROL NS 10 MG/ML SPRAY | $12.78 per ml | |