II. Indications

III. Pharmacokinetics

  1. Half-Life: 24 to 100 hours

IV. Flurazepam (Dalmane)

  1. Dose: 15-30 mg PO qhs

V. Dosing

  1. Max Daily Dose: 30 mg

VI. Cost

  1. 7 day cost: $1.50

VII. Precautions

  1. Drug accumulation in elderly

VIII. Side Effects

IX. Advantages

  1. Long half life prevents rebound Insomnia
    1. often seen in other Benzodiazepines used >30 days

X. Equivalents for Withdrawal protocol

  1. Valium = Flurazepam Dose x 0.6
  2. Phenobarbital = Flurazepam Dose x2.0

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

flurazepam (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
FLURAZEPAM 15 MG CAPSULE Generic $0.35 each
FLURAZEPAM 30 MG CAPSULE Generic $0.51 each

Ontology: Flurazepam (C0016375)

Definition (NCI) A member of the benzodiazepines and a long-acting depressor of the central nervous system (CNS) with sedative and hypnotic effects. Flurazepam binds to a specific site on the benzodiazepine-gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability. By modulating binding of the GABA inhibitory neurotransmitter to GABA-A receptors in the ascending reticular activating system, flurazepam blocks arousal of the cortical and limbic system, thereby exerting its sedative and hypnotic effect.
Definition (MSH) A benzodiazepine derivative used mainly as a hypnotic.
Definition (PSY) Organic heterocyclic compound, used as a benzodiazepine tranquilizer and a nonbarbiturate sedative.
Definition (CSP) benzodiazepine derivative used mainly as a sedative and hypnotic in the treatment of insomnia.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D005479
SnomedCT 19403009, 387109000
LNC LP16153-6, MTHU003487
English Flurazepam, flurazepam, 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Flurazepam [Chemical/Ingredient], 7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, FLURAZEPAM, Flurazepam (product), Flurazepam (substance)
Swedish Flurazepam
Czech flurazepam
Finnish Fluratsepaami
Japanese フルラゼパム
Spanish fluracepam (producto), fluracepam, flurazepam (producto), fluracepam (sustancia), flurazepam (sustancia), flurazepam, Flurazepam
Polish Flurazepam
French Flurazépam
German Flurazepam
Italian Flurazepam
Portuguese Flurazepam

Ontology: Dalmane (C0733803)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D005479
English dalmane, Dalmane, Allphar Brand of Flurazepam Monohydrochloride, Dalmadorm, Dormodor, ICN Brand of Flurazepam Monohydrochloride