|
Definition (NCI_NCI-GLOSS)
|
A drug that slows the metabolism of retinoids, allowing them to act over a longer period of time.
|
|
Definition (NCI)
|
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol metabolite acetaldehyde into acetic acid. This leads to an accumulation of acetaldehyde that produces a variety of very unpleasant symptoms referred to as the disulfiram-alcohol reaction. This reaction includes , but is not limited to, flushing, headache, respiratory difficulty, nausea,vomiting, sweating, thirst, chest pain, tachycardia, blurred vision and hypotension.
|
|
Definition (MSH)
|
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
|
|
Definition (CSP)
|
carbamate derivative used as an alcohol deterrent; it is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol; when alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome); it acts by inhibiting aldehyde dehydrogenase.
|
|
Definition (PDQ)
|
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol metabolite acetaldehyde into acetic acid. This leads to an accumulation of acetaldehyde that produces a variety of very unpleasant symptoms referred to as the disulfiram-alcohol reaction. This reaction includes , but is not limited to, flushing, headache, respiratory difficulty, nausea,vomiting, sweating, thirst, chest pain, tachycardia, blurred vision and hypotension. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42291&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42291&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C447" NCI Thesaurus)
|
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D004221
|
| SnomedCT |
39516004, 387212009, 256160001, 411488001 |
| LNC |
LP16119-7, MTHU006972 |
| English |
Bis(diethylthiocarbamoyl) Disulfide, Disulfide, Tetraethylthiuram, Tetraethylthiuram Disulfide, disulfiram, Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-, TTD, Tetraethylthioperoxydicarbonic Diamide, Teturamin, DS, Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2, Disulphiram product, Disulphiram, disulfiram (medication), DISULFIRAM, Disulfiram [Chemical/Ingredient], disulphiram, tetraethylthiuram disulfide, Tetraethylthiuram disulfide (substance), Tetraethylthiuram disulfide (product), Tetraethylthiuram disulfide, Tetraethylthiuram disulphide, Disulfiram product, Disulfiram (product), Disulfiram (substance), Disulfiram |
| Swedish |
Disulfiram
|
| Czech |
disulfiram
|
| Finnish |
Disulfiraami
|
| Russian |
ANTABUS, ETILDITIURAM, TETURAM, DISUL'FIRAM, TETRAETILTIURAMDISUL'FID, АНТАБУС, ДИСУЛЬФИРАМ, ТЕТРАЭТИЛТИУРАМДИСУЛЬФИД, ТЕТУРАМ, ЭТИЛДИТИУРАМ |
| Japanese |
ジスルフィラム, テトラエチルチウラムジスルフィド |
| French |
Disulfiram, Disulfirame |
| Italian |
Disulfuro tetraetiltiuramo, Disulfiram |
| Croatian |
DISULFIRAM
|
| Polish |
Antabus, Disulfiram, Anicol |
| Spanish |
disulfuro de tetraetiltiuram (producto), disulfuro de tetraetiltiuram, disulfuro de tetraetiltiuram (sustancia), disulfiram (producto), disulfiram (sustancia), disulfiram, tetraetiltiuram disulfuro, Disulfiram, Disulfuro de Tetraetiltiuramo |
| Portuguese |
Tetraetiltiuramo Dissulfeto, Dissulfeto de Tetraetiltiuramo, Dissulfiram |
| German |
Disulfiram, Tetraethylthiuramdisulfid |
