II. Indications
- Abdominal Surgery prophylaxis
- Colorectal surgery prophylaxis
III. Mechanism
- Antibiotics in this group are Cephamycin derivatives
-
Antibiotic coverage spectrum
- Gram Positive activity (but less than Second Generation Broad-spectrum Cephalosporins such as Cefuroxime)
- Gram Negative coverage (similar to Third Generation Cephalosporins)
- Anaerobic coverage (e.g. Bacteroides)
IV. Dosing
- Adult
- Typical Dosing
- Give 1-2 grams IM or IV every 12 hours
- Surgical Prophylaxis
- Give 1 to 2 g IV 30 to 60 min before surgery (or for Cesarean Section, after Umbilical Cord clamped)
- Renal Dosing
- eGFR 10 to 30 ml/min: Give typical dose every 24 hours
- eGFR <10 ml/min: Give typical dose every 48 hours
- Typical Dosing
- Child (Not FDA approved)
- Give 40 to 80 mg/kg/day IV divided every 12 hours
V. Adverse Effects
VI. Safety
- Pregnancy Category B
- Safe in Lactation
VII. Drug Interactions
-
Alcohol
- Disulfiram reaction (Antabuse-like effect)
VIII. Resources
IX. References
- (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
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Definition (NCI) | A semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin antibiotic derived from cephalosporium. The bactericidal activity of cefotetan disodium is caused by an inhibition of bacterial cell wall synthesis via inhibition of cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Cefotetan disodium is more active against gram-negative organisms and less active against gram-positive organisms compared to first-generation cephalosporins. |
Definition (MSH) | A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | D015313 |
SnomedCT | 13585009, 370355004 |
LNC | LP15066-1, MTHU001385 |
English | Cefotetan, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7alpha))-, cefotetan (medication), Cefotetan [Chemical/Ingredient], CEFOTETAN, cefoTEtan, cefotetan, Cefotetan (substance), Cefotetan product (product), Cefotetan product |
Swedish | Cefotetan |
Czech | cefotetan |
Finnish | Kefotetaani |
Russian | TSEFOTETAN, ЦЕФОТЕТАН |
Japanese | セフォテタン |
Spanish | producto con cefotetán (producto), cefotetán (producto), producto con cefotetán, Cefotetán, cefotetán (sustancia), cefotetán |
Polish | Cefotetan |
French | Céfotétan |
German | Cefotetan |
Italian | Cefotetan |
Portuguese | Cefotetan |