II. Indications

  1. Abdominal Surgery prophylaxis
  2. Colorectal surgery prophylaxis

III. Mechanism

  1. Antibiotics in this group are Cephamycin derivatives
  2. Antibiotic coverage spectrum
    1. Gram Positive activity (but less than Second Generation Broad-spectrum Cephalosporins such as Cefuroxime)
    2. Gram Negative coverage (similar to Third Generation Cephalosporins)
    3. Anaerobic coverage (e.g. Bacteroides)

IV. Dosing

  1. Adult
    1. Typical Dosing
      1. Give 1-2 grams IM or IV every 12 hours
    2. Surgical Prophylaxis
      1. Give 1 to 2 g IV 30 to 60 min before surgery (or for Cesarean Section, after Umbilical Cord clamped)
    3. Renal Dosing
      1. eGFR 10 to 30 ml/min: Give typical dose every 24 hours
      2. eGFR <10 ml/min: Give typical dose every 48 hours
  2. Child (Not FDA approved)
    1. Give 40 to 80 mg/kg/day IV divided every 12 hours

V. Adverse Effects

VI. Safety

  1. Pregnancy Category B
  2. Safe in Lactation

VII. Drug Interactions

  1. Alcohol
    1. Disulfiram reaction (Antabuse-like effect)

IX. References

  1. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins

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Ontology: Cefotetan (C0007555)

Definition (NCI) A semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin antibiotic derived from cephalosporium. The bactericidal activity of cefotetan disodium is caused by an inhibition of bacterial cell wall synthesis via inhibition of cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Cefotetan disodium is more active against gram-negative organisms and less active against gram-positive organisms compared to first-generation cephalosporins.
Definition (MSH) A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D015313
SnomedCT 13585009, 370355004
LNC LP15066-1, MTHU001385
English Cefotetan, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7alpha))-, cefotetan (medication), Cefotetan [Chemical/Ingredient], CEFOTETAN, cefoTEtan, cefotetan, Cefotetan (substance), Cefotetan product (product), Cefotetan product
Swedish Cefotetan
Czech cefotetan
Finnish Kefotetaani
Russian TSEFOTETAN, ЦЕФОТЕТАН
Japanese セフォテタン
Spanish producto con cefotetán (producto), cefotetán (producto), producto con cefotetán, Cefotetán, cefotetán (sustancia), cefotetán
Polish Cefotetan
French Céfotétan
German Cefotetan
Italian Cefotetan
Portuguese Cefotetan