II. Indications: Malaria Prophylaxis and Treatment
- Areas with Chloroquine resistance
- Not recommended for routine prophylaxis
- Treatment in breakthrough Chloroquine Resistance
III. Medications
- Tablet: Pyrimethamine 25 mg and sulfadoxine 500 mg
- Taking with food decreases gastric irritation
IV. Dosing: Prophylaxis
- Adult (and age >=14 years)
- Pyrimethamine Sulfadoxine 25/500 mg tablet orally each week
- Child (age <14 years)
- Age 2-11 months: 1/8 tablet orally each week
- Age 1-3 years: 1/4 tablet orally each week
- Age 4-8 years: 1/2 tablet orally each week
- Age 9-14 years: 3/4 tablet orally each week
V. Dosing: Treatment
- Adult: 75/1500 mg for one dose
- Child: Double dose of prophylactic dose
VI. Adverse Effects
- See Pyrimethamine
VII. Resources
- Pyrimethamine Sulfadoxine (pdf from FDA access data)