II. Indications: Malaria Prophylaxis and Treatment

  1. Areas with Chloroquine resistance
  2. Not recommended for routine prophylaxis
  3. Treatment in breakthrough Chloroquine Resistance

III. Medications

  1. Tablet: Pyrimethamine 25 mg and sulfadoxine 500 mg
    1. Taking with food decreases gastric irritation

IV. Dosing: Prophylaxis

  1. Adult (and age >=14 years)
    1. Pyrimethamine Sulfadoxine 25/500 mg tablet orally each week
  2. Child (age <14 years)
    1. Age 2-11 months: 1/8 tablet orally each week
    2. Age 1-3 years: 1/4 tablet orally each week
    3. Age 4-8 years: 1/2 tablet orally each week
    4. Age 9-14 years: 3/4 tablet orally each week

V. Dosing: Treatment

  1. Adult: 75/1500 mg for one dose
  2. Child: Double dose of prophylactic dose

VI. Adverse Effects

VII. Resources

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Related Studies

Ontology: Fansidar (C0060061)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C001205
English Fansidar, fansidar

Ontology: Pyrimethamine / Sulfadoxine (C0700599)

Definition (NCI) A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. Sulfadoxine competitively antagonizes paraaminobenzoic acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis. Sulfadoxine acts synergistically with pyrimethamine. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C001205
SnomedCT 398770008, 53357005
English pyrimethamine-sulfadoxine, sulphadoxine-pyrimethamine, PYRIMETHAMINE/SULFADOXINE, Pyrimethamine + sulphadoxine, sulfadoxine + pyrimethamine, sulfadoxine + pyrimethamine (medication), Pyrimethamine + Sulphadoxine, Pyrimethamine + Sulfadoxine, Pyrimethamine / Sulfadoxine, fanasil, pyrimethamine drug combination, sulfadoxine-pyrimethamine, fanasil - pyrimethamine, Pyrimethamine with sulfadoxine, Pyrimethamine-sulphadoxine, Pyrimethamine-sulfadoxine, Pyrimethamine with sulphadoxine, Pyrimethamine with sulfadoxine (substance), Pyrimethamine + sulfadoxine (product), Pyrimethamine + sulfadoxine, pyrimethamine sulfadoxine, Pyrimethamine Sulfadoxine, Pyrimethamine-Sulfadoxine, Sulfadoxine and Pyrimethamine
Spanish pirimetamina-sulfadoxina, pirimetamina-sulfadoxina (sustancia), pirimetamina con sulfadoxina, pirimetamina + sulfadoxina (producto), pirimetamina + sulfadoxina