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Ontology:
Fansidar
(C0060061)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
C001205
|
| English |
Fansidar, fansidar |
Ontology:
Daraprim
(C0591326)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D011739
|
| English |
Daraprim, Glaxo Wellcome Brand of Pyrimethamine, GlaxoSmithKline Brand of Pyrimethamine, Wellcome Brand of Pyrimethamine |
Ontology:
Pyrimethamine / Sulfadoxine
(C0700599)
|
Definition (NCI)
|
A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. Sulfadoxine competitively antagonizes paraaminobenzoic acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis. Sulfadoxine acts synergistically with pyrimethamine. (NCI04)
|
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
C001205
|
| SnomedCT |
398770008, 53357005 |
| English |
pyrimethamine-sulfadoxine, sulphadoxine-pyrimethamine, PYRIMETHAMINE/SULFADOXINE, Pyrimethamine + sulphadoxine, sulfadoxine + pyrimethamine, sulfadoxine + pyrimethamine (medication), Pyrimethamine + Sulphadoxine, Pyrimethamine + Sulfadoxine, Pyrimethamine / Sulfadoxine, fanasil, pyrimethamine drug combination, sulfadoxine-pyrimethamine, fanasil - pyrimethamine, Pyrimethamine with sulfadoxine, Pyrimethamine-sulphadoxine, Pyrimethamine-sulfadoxine, Pyrimethamine with sulphadoxine, Pyrimethamine with sulfadoxine (substance), Pyrimethamine + sulfadoxine (product), Pyrimethamine + sulfadoxine, pyrimethamine sulfadoxine, Pyrimethamine Sulfadoxine, Pyrimethamine-Sulfadoxine, Sulfadoxine and Pyrimethamine |
| Spanish |
pirimetamina-sulfadoxina, pirimetamina-sulfadoxina (sustancia), pirimetamina con sulfadoxina, pirimetamina + sulfadoxina (producto), pirimetamina + sulfadoxina |
