II. Indications: Malaria Prophylaxis and Treatment
- Areas with Chloroquine resistance
- Not recommended for routine prophylaxis
- Treatment in breakthrough Chloroquine Resistance
III. Medications
- Tablet: Pyrimethamine 25 mg and sulfadoxine 500 mg
- Taking with food decreases gastric irritation
IV. Dosing: Prophylaxis
- Adult (and age >=14 years)
- Pyrimethamine Sulfadoxine 25/500 mg tablet orally each week
- Child (age <14 years)
- Age 2-11 months: 1/8 tablet orally each week
- Age 1-3 years: 1/4 tablet orally each week
- Age 4-8 years: 1/2 tablet orally each week
- Age 9-14 years: 3/4 tablet orally each week
V. Dosing: Treatment
- Adult: 75/1500 mg for one dose
- Child: Double dose of prophylactic dose
VI. Adverse Effects
- See Pyrimethamine
VII. Resources
- Pyrimethamine Sulfadoxine (pdf from FDA access data)
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Related Studies
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C001205 |
English | Fansidar, fansidar |
Ontology: Pyrimethamine / Sulfadoxine (C0700599)
Definition (NCI) | A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. Sulfadoxine competitively antagonizes paraaminobenzoic acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis. Sulfadoxine acts synergistically with pyrimethamine. (NCI04) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C001205 |
SnomedCT | 398770008, 53357005 |
English | pyrimethamine-sulfadoxine, sulphadoxine-pyrimethamine, PYRIMETHAMINE/SULFADOXINE, Pyrimethamine + sulphadoxine, sulfadoxine + pyrimethamine, sulfadoxine + pyrimethamine (medication), Pyrimethamine + Sulphadoxine, Pyrimethamine + Sulfadoxine, Pyrimethamine / Sulfadoxine, fanasil, pyrimethamine drug combination, sulfadoxine-pyrimethamine, fanasil - pyrimethamine, Pyrimethamine with sulfadoxine, Pyrimethamine-sulphadoxine, Pyrimethamine-sulfadoxine, Pyrimethamine with sulphadoxine, Pyrimethamine with sulfadoxine (substance), Pyrimethamine + sulfadoxine (product), Pyrimethamine + sulfadoxine, pyrimethamine sulfadoxine, Pyrimethamine Sulfadoxine, Pyrimethamine-Sulfadoxine, Sulfadoxine and Pyrimethamine |
Spanish | pirimetamina-sulfadoxina, pirimetamina-sulfadoxina (sustancia), pirimetamina con sulfadoxina, pirimetamina + sulfadoxina (producto), pirimetamina + sulfadoxina |