II. Indications
- See Erythromycin
III. Mechanism
- See Macrolide
IV. Adverse Effects
- See Erythromycin
V. Drug Interactions
- See Macrolide
VI. Dosing
- Dose: 15 to 20 mg/kg/day divided every 6 hours IV
- Maximum: 4 grams/day
VII. Adverse Effects
- See Erythromycin
- Venous Irritation
- Administer solution in diluted form and slowly
- Myasthenia Gravis exacerbation
- Hypertrophic Pyloric Stenosis (age <45 days)
-
QT Prolongation
- Class effect with Macrolides
- Three fold increased risk of Sudden Cardiac Death while on Azithromycin
- Higher risk with known QTc Prolongation, Hypokalemia, Hypomagnesemia, Class IA or III Antiarrhythmics
- Ray (2013) N Engl J Med 366(20): 1881-90 [PubMed]
VIII. Drug Interactions
- Strong CYP3A4 Inhibitor
- Numerous Drug Interactions
- Serious interactions resulting in death have occurred
-
Warfarin
- May increase INR
IX. Safety
- Pregnancy Category B
- Considered safe in Lactation
X. Resources
- Erythromycin Lactobionate (DailyMed)