II. Indications

III. Mechanism

  1. See Macrolide

IV. Adverse Effects

V. Drug Interactions

  1. See Macrolide

VI. Dosing

  1. Dose: 15 to 20 mg/kg/day divided every 6 hours IV
  2. Maximum: 4 grams/day

VII. Adverse Effects

  1. See Erythromycin
  2. Venous Irritation
    1. Administer solution in diluted form and slowly
  3. Myasthenia Gravis exacerbation
  4. Hypertrophic Pyloric Stenosis (age <45 days)
  5. QT Prolongation
    1. Class effect with Macrolides
    2. Three fold increased risk of Sudden Cardiac Death while on Azithromycin
    3. Higher risk with known QTc Prolongation, Hypokalemia, Hypomagnesemia, Class IA or III Antiarrhythmics
    4. Ray (2013) N Engl J Med 366(20): 1881-90 [PubMed]

VIII. Drug Interactions

  1. Strong CYP3A4 Inhibitor
    1. Numerous Drug Interactions
    2. Serious interactions resulting in death have occurred
  2. Warfarin
    1. May increase INR

IX. Safety

  1. Pregnancy Category B
  2. Considered safe in Lactation

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