II. Preparations: Class I - Sodium Channel Blockade
- Class Ia: Lengthens Action Potential duration
- Quinidine
- Procainamide (Pronestyl)
- Disopyramide (Norpace)
- Amiodarone (also Class II, III, IV)
- Several non-classic Antiarrhythmics have Class Ia activity (e.g. Imipramine, a Tricyclic Antidepressant)
- Class Ib: Shortens Action Potential duration
- Class Ic: Slows conduction
- Precautions
- Increased proarrhythmia risk and risk of Sudden Cardiac Death
- Avoid in structural heart disease, Coronary Artery Disease and Left Ventricular Hypertrophy
- Must use with concurrent AV Nodal Blocking agent (e.g. Beta Blocker)
- Flecainide (Tambocor)
- Encainide (Enkaid)
- Propafenone (Rythmol)
- Precautions
III. Preparations: Class II - Beta Blocker
- Propranolol
- Metoprolol
- Atenolol
- Carvedilol (Coreg)
- Esmolol (Brevibloc)
- Sotalol (also Class III)
- Amiodarone (also Class Ia, III, IV)
IV. Preparations: Class III - Blocks potassiun channels, prolongs repolarization
- Bretylium (Bretylol)
- Sotalol
- Amiodarone (also Class Ia, II, IV)
- Dofetilide (Tikosyn)
- Dronedarone (Multaq)
V. Preparations: Class IV - Calcium Channel Blocker, blocks slow Calcium channel
- Verapamil (Calan)
- Diltiazem (Cardizem)
- Nifedipine
- Amiodarone (also Class Ia, II, III)
VI. References
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Related Studies
| Definition (NCI) | Agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.(CRISP) |
| Definition (MSH) | Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. |
| Definition (CSP) | group of agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. |
| Concepts | Pharmacologic Substance (T121) |
| MSH | D000889 |
| SnomedCT | 67507000, 372813008 |
| English | Agents, Anti-Arrhythmia, Anti Arrhythmia Agents, antiarrhythmic agent, Agents, Antiarrhythmia, Anti Arrhythmia Drugs, Anti Arrhythmics, Anti-Arrhythmia Drugs, Anti-Arrhythmics, Antiarrhythmia Agents, Antiarrhythmia Drugs, Antiarrhythmic Drugs, Drugs, Anti-Arrhythmia, Drugs, Antiarrhythmia, Drugs, Antiarrhythmic, Antiarrhythmic Agent, ANTIARRHYTHMIA AGENTS, ANTIARRHYTHMICS, antiarrhythmic agents (medication), anti-arrhythimia agents, antiarrhythmic agents, Cardiac Depressant, Antiarrhythmic, Anti-arrhythmic Agent, [CV300] ANTIARRHYTHMICS, Anti-arrhythmic, Anti-arrhythmic Agent [TC], agents antiarrhythmic, antiarrhythmia drugs, antiarrhythmic drugs, anti arrhythmia drugs, anti arrhythmic, antiarrhythmic, anti arrhythmics, anti-arrhythmia drugs, antiarrhythmia agents, anti-arrhythmics, antiarrhythmic drug, antiarrhythmics, Anti-Arrhythmia Agents, Antiarrhythmic drug, Antiarrhythmic agent (substance), Antiarrhythmic agent, Antiarrhythmic drug (product), Antiarrhythmic drug, NOS, Antiarrhythmic drug (substance), antiarrhythmia, Antiarrhythmics |
| French | Médicaments antiarythmiques, Anti-arythmiques, Agents antiarythmiques, Antiarythmisants, Antiarythmiques |
| Swedish | Antiarytmika |
| Czech | antiarytmika |
| Finnish | Rytmihäiriölääkkeet |
| Italian | Farmaci antiaritmia, Farmaci antiaritmici, Antiaritmici |
| Russian | PROTIVOARITMICHESKIE SREDSTVA, MIOKARDIAL'NYE DEPRESSANTY, KARDIAL'NYE DEPRESSANTY, ANTIARITMICHESKIE SREDSTVA, ANTIFIBRILLIATORNYE SREDSTVA, АНТИАРИТМИЧЕСКИЕ СРЕДСТВА, АНТИФИБРИЛЛЯТОРНЫЕ СРЕДСТВА, КАРДИАЛЬНЫЕ ДЕПРЕССАНТЫ, МИОКАРДИАЛЬНЫЕ ДЕПРЕССАНТЫ, ПРОТИВОАРИТМИЧЕСКИЕ СРЕДСТВА |
| Japanese | 抗不整脈薬, 不整脈治療薬, 心筋抑制薬, 心抑制薬, 抗不整脈剤, 抗心臓細動薬 |
| Croatian | ANTIARITMIJSKI LIJEKOVI |
| Polish | Leki przeciwarytmiczne, Depresanty mięśnia sercowego, Antyarytmiki, Leki antyarytmiczne |
| Spanish | Antiarrítmicos, Agentes Antiarrítmicos, agente antiarrítmico (sustancia), agente antiarrítmico, antiarrítmicos, antiarrítmico, droga antiarrítmica (producto), droga antiarrítmica (sustancia), droga antiarrítmica, fármaco antiarrítmico (producto), fármaco antiarrítmico |
| Portuguese | Agentes Antiarrítmicos, Antiarrítmicos |
| German | Antiarrhythmika |
Ontology: Class Ia antiarrhythmic drug (C0304503)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 373269000, 6122008 |
| English | Class Ia antiarrhythmic agent (substance), Class Ia antiarrhythmic agent, Class Ia antiarrhythmic drug (product), Class Ia antiarrhythmic drug, Class Ia antiarrhythmic drug, NOS, Class Ia antiarrhythmic drug (substance) |
| Spanish | agente antiarrítmico clase Ia (sustancia), agente antiarrítmico clase Ia, droga antiarrítmica, clase Ia (sustancia), fármaco antiarrítmico, clase Ia (producto), fármaco antiarrítmico, clase Ia |
Ontology: Class Ib antiarrhythmic drug (C0304504)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 373286006, 80066008 |
| English | Class Ib antiarrhythmic agent (substance), Class Ib antiarrhythmic agent, Class Ib antiarrhythmic drug (product), Class Ib antiarrhythmic drug, Class Ib antiarrhythmic drug, NOS, Class Ib antiarrhythmic drug (substance) |
| Spanish | agente antiarrítmico, clase Ib (sustancia), agente antiarrítmico, clase Ib, droga antiarrítmica, clase Ib (sustancia), fármaco antiarrítmico, clase Ib (producto), fármaco antiarrítmico, clase Ib |
Ontology: Class Ic antiarrhythmic drug (C0304505)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 373290008, 86317005 |
| English | Class Ic antiarrhythmic agent (substance), Class Ic antiarrhythmic agent, Class Ic antiarrhythmic drug (product), Class Ic antiarrhythmic drug, Class Ic antiarrhythmic drug, NOS, Class Ic antiarrhythmic drug (substance) |
| Spanish | agente antiarrítmico, clase Ic (sustancia), agente antiarrítmico, clase Ic, droga antiarrítmica, clase Ic (sustancia), fármaco antiarrítmico, clase Ic (producto), fármaco antiarrítmico, clase Ic |
Ontology: Class I antiarrhythmic drug (C0360692)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 371179002, 49590009, 373260001 |
| English | Class I antiarrhythmic agent (product), Class I antiarrhythmic, Class I antiarrhythmic agent (substance), Class I antiarrhythmic agent, Class I antiarrhythmic drug (product), Class I antiarrhythmic drug, Class I antiarrhythmic drug, NOS, Class I antiarrhythmic drug (substance) |
| Spanish | agente antiarrítmico, clase I, agente antiarrítmico, clase I (producto), agente antiarrítmico clase I (sustancia), agente antiarrítmico clase I, droga antiarrítmica, clase I (sustancia), fármaco antiarrítmico, clase I (producto), fármaco antiarrítmico, clase I |
Ontology: Class II antiarrhythmic drug (C0360701)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 371183002, 69227005, 373278006 |
| English | Class II antiarrhythmic agent (product), Class II antiarrhythmic, Class II antiarrhythmic agent (substance), Class II antiarrhythmic agent, Class II antiarrhythmic drug (product), Class II antiarrhythmic drug, Class II antiarrhythmic drug, NOS, Class II antiarrhythmic drug (substance), Antiarrhythmics - Class II |
| Spanish | agente antiarrítmico, clase II (producto), agente antiarrítmico, clase II (sustancia), agente antiarrítmico, clase II, droga antiarrítmica, clase II (sustancia), fármaco antiarrítmico, clase II (producto), fármaco antiarrítmico, clase II |
Ontology: Class III antiarrhythmic drug (C0360703)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 371184008, 79808008, 372855004 |
| English | antiarrhythmics class iii, antiarrhythmic class drugs iii, class iii antiarrhythmic drug, Class III antiarrhythmic agent (product), Class III antiarrhythmic, Class III antiarrhythmic agent (substance), Class III antiarrhythmic agent, Class III antiarrhythmic drug (product), Class III antiarrhythmic drug, Class III antiarrhythmic drug, NOS, Class III antiarrhythmic drug (substance), Antiarrhythmics - Class III |
| Spanish | agente antiarrítmico, clase III, agente antiarrítmico, clase III (producto), agente antiarrítmico clase III (sustancia), agente antiarrítmico clase III, droga antiarrítmica, clase III (sustancia), fármaco antiarrítmico, clase III (producto), fármaco antiarrítmico, clase III |
Ontology: Class IV antiarrhythmic drug (C0360706)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 371185009, 29883004, 372693007 |
| Spanish | droga antiarrítmica, clase IV, agente antiarrítmico, clase IV (producto), agente antiarrítmico, clase IV, agente antiarrítmico clase IV (sustancia), agente antiarrítmico clase IV, droga antiarrítmica, clase IV (producto), droga antiarrítmica, clase IV (sustancia), fármaco antiarrítmico, clase IV (producto), fármaco antiarrítmico, clase IV |
| English | Class IV antiarrhythmic agent (product), Class IV antiarrhythmic, Class IV antiarrhythmic agent (substance), Class IV antiarrhythmic agent, Class IV antiarrhythmic drug (product), Class IV antiarrhythmic drug, Class IV antiarrhythmic drug, NOS, Class IV antiarrhythmic drug (substance), Antiarrhythmics - Class IV |
Ontology: Potassium Channel Blockers (C0872245)
| Definition (MSH) | A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS. |
| Concepts | Pharmacologic Substance (T121) |
| MSH | D026902 |
| SnomedCT | 415151000, 415152007 |
| French | Bloqueurs du canal potassique, Inhibiteurs du canal potassium, Inhibiteurs des canaux potassiques, Inhibiteurs du canal potassique, Bloqueurs des canaux potassium, Inhibiteurs des canaux potassium, Bloqueurs des canaux potassiques, Antagonistes des canaux potassiques |
| Swedish | Kaliumkanalblockerare |
| English | K CHANNEL BLOCK, CHANNEL BLOCK K, potassium channel blockers, potassium channel blocker, Blockers, Potassium Channel, Channel Blockers, Potassium, Potassium Channel Blockers, Potassium channel antagonist (product), Potassium channel antagonist (substance), Potassium channel antagonist, Potassium channel blocker |
| Czech | draslíkové kanály - blokátory |
| Finnish | Kaliumkanavansalpaajat |
| Russian | BLOKATORY KALIEVYKH KANALOV, KALIEVYKH KANALOV BLOKATORY, KANALOV KALIEVYKH BLOKATORY, БЛОКАТОРЫ КАЛИЕВЫХ КАНАЛОВ, КАЛИЕВЫХ КАНАЛОВ БЛОКАТОРЫ, КАНАЛОВ КАЛИЕВЫХ БЛОКАТОРЫ |
| Japanese | カリウムチャネル遮断薬, カリウムチャネル遮断剤, カリウムチャンネル遮断剤, Kチャネル遮断剤, Kチャネル遮断薬 |
| Spanish | Bloqueantes de los Canales de Potasio, antagonista del canal de potasio (producto), antagonista del canal de potasio (sustancia), antagonista del canal de potasio, bloqueante del canal de potasio, Bloqueadores de los Canales de Potasio |
| Polish | Blokery kanałów potasowych |
| German | Kaliumkanal-Blocker, Kanalblocker, Kalium- |
| Italian | Bloccanti del canale del potassio |
| Portuguese | Bloqueadores dos Canais de Potássio |
