II. Indication
- Ventricular Arrhythmia
- Supraventricular Arrhythmia
- Atrial Fibrillation Cardioversion
- Time to Cardioversion: 3-6 hours
- Conversion Rate: 20-52%
- Chronic Efficacy: 50-60%
- Atrial Fibrillation Cardioversion
III. Mechanism
- Class III Antiarrhythmic
- Prolongs Action Potential duration
- Increases cardiac tissue refractoriness
- Class II Antiarrhythmic
- Non-selective Beta Blocker
IV. Adverse Effects
- Bradycardia
- Hypotension
- Proarrhythmia (Torsades de Pointes)
- Associated with doses over 320 mg per day
V. Dosing: Oral
- Starting Dose: 80 mg PO bid
- Typical dosing: 80-160 mg PO bid
- Maximum: 640 mg per day
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