II. Indication

  1. Ventricular Arrhythmia
  2. Supraventricular Arrhythmia
    1. Atrial Fibrillation Cardioversion
      1. Time to Cardioversion: 3-6 hours
      2. Conversion Rate: 20-52%
      3. Chronic Efficacy: 50-60%

III. Mechanism

  1. Class III Antiarrhythmic
    1. Prolongs Action Potential duration
    2. Increases cardiac tissue refractoriness
  2. Class II Antiarrhythmic
    1. Non-selective Beta Blocker

IV. Adverse Effects

  1. Bradycardia
  2. Hypotension
  3. Proarrhythmia (Torsades de Pointes)
    1. Associated with doses over 320 mg per day

V. Dosing: Oral

  1. Starting Dose: 80 mg PO bid
  2. Typical dosing: 80-160 mg PO bid
  3. Maximum: 640 mg per day

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