II. Indications
-
Hypertension
- Not first-line Antihypertensives, and avoid using as monotherapy (higher risk of CVA and CHF)
-
Benign Prostatic Hypertrophy
- Selective Alpha-1a Antagonists (e.g. Tamsulosin) are preferred
-
Medical Expulsive Therapy for Ureteral Stone
- Replaced by the preferred Selective Alpha-1a Antagonists (e.g. Tamsulosin)
III. Dosing
-
Hypertension
- Start: 1 mg orally at bedtime and titrate dose (Maximum 16 mg/day)
-
Benign Prostatic Hypertrophy (replaced by Selective Alpha-1a Antagonists)
- Start: 1 mg orally at bedtime and titrate every 1-2 weeks doubling dose, to a maximum of 8 mg at bedtime
- Extended release formulation (e.g. Cardura XL) 4 mg in am daily (may increase to 8 mg daily after 3-4 weeks)
-
Medical Expulsive Therapy for Ureteral Stone (replaced by Selective Alpha-1a Antagonists)
- Extended release formulation (e.g. Cardura XL) 4 mg orally daily (not FDA approved)
IV. Safety
- Unknown safety in Pregnancy
- Unknown safety in Lactation
V. Mechanism
- See Alpha Adrenergic Receptor (Alpha-1 Antagonist)
-
Peripheral Alpha-1 Adrenergic Antagonist
- Arterial and Venous Vasodilation
VI. Adverse Effects
VII. Drug Interactions
- Strong CYP3A4 Inhibitors (e.g. Clarithromycin, Itraconazole)
- Risk of increased Doxazosin effects (e.g. Orthostatic Hypotension)
VIII. Resources
IX. References
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
Images: Related links to external sites (from Bing)
Related Studies
| doxazosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DOXAZOSIN MESYLATE 1 MG TAB | Generic | $0.09 each |
| DOXAZOSIN MESYLATE 2 MG TAB | Generic | $0.07 each |
| DOXAZOSIN MESYLATE 4 MG TAB | Generic | $0.09 each |
| DOXAZOSIN MESYLATE 8 MG TAB | Generic | $0.11 each |