II. Effects: Alpha Receptor General
- Vascular Smooth Muscle
- Skin and skeletal Muscle vessel constriction
- Splanchnic vessel constriction
- Gastrointestinal
- Myenteric Plexus Inhibition
- Genitourinary
- Skin
- Pilomotor smooth Muscle Contraction
- Apocrine gland contraction
- Metabolic
- Gluconeogenesis
- Glycogenolysis
III. Effects: Alpha 1 Receptors
- Vascular Smooth Muscle postsynaptic Neurons
- Vasoconstriction
-
Myocardium
- Positive Inotrope (increase cardiac contractility)
- Negative Chronotrope (decrease Heart Rate)
- Eye
- Radial Muscle Contraction (dilate pupils)
- Gastrointestinal and Genitourinary
- Sphincter (e.g. anus) contraction
IV. Effects: Alpha 2 Receptors
- Peripheral Alpha 2 Receptors
- Vascular Smooth Muscle (mixed effect)
- Modulates large vessel tone
- Arteriolar and venous Vasoconstriction
- Opposes alpha 1 receptor Vasoconstriction
- Inhibits Norepinephrine release
- Decreases adrenergic activity
- Gastrointestinal
- Smooth Muscle wall relaxation
- Metabolic
- Fat Cell Lipolysis
- Vascular Smooth Muscle (mixed effect)
- Central Alpha 2 Receptors (CNS)
- Inhibits Locus Ceruleus reflex arc
- Peripheral vasodilatation
V. Medications: Alpha Adrenergics
- Alpha Adrenergic Agonist (Alpha Adrenergic Receptor)
- Alpha Non-Specific
- Alpha 1 Selective
- Phenylephrine
- Methoxamine
- Alpha 2 Selective
- Clonidine (See Central Adrenergic Agonist)
- Alpha-methylnorepinephrine
- Alpha Receptor Antagonist
- Alpha Non-Specific
- Alpha 1 Selective
- Alpha 2 Selective
- Yohimbine
- Tolazoline
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Related Studies
Definition (MSH) | A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS. |
Concepts | Receptor (T192) , Amino Acid, Peptide, or Protein (T116) |
MSH | D018340 |
English | Adrenergic Receptor, alpha-1, Adrenergic Receptors, alpha-1, alpha 1 Adrenergic Receptors, alpha-1 Adrenergic Receptor, alpha-1 Adrenergic Receptors, Receptor, alpha-1 Adrenergic, Receptors, alpha-1 Adrenergic, Receptor, Adrenergic, alpha-1, alpha 1 Adrenergic Receptor, Adrenergic alpha-1 Receptors, Receptors, Adrenergic, alpha-1, Adrenergic Receptor, alpha 1, Receptors, Adrenergic alpha-1, Receptors, alpha 1 Adrenergic, alpha-1 Receptors, Adrenergic, RECEPT ADREN ALPHA 1, ALPHA 1 ADREN RECEPT, ADRENERGIC RECEPTORS ALPHA 01, ADREN ALPHA 1 RECEPT, ALPHA ADRENERGIC RECEPTORS 01, RECEPTORS ALPHA 1 ADRENERGIC, RECEPT ALPHA 1 ADREN, Receptors, Adrenergic, alpha-1 [Chemical/Ingredient], Adrenergic alpha 1 Receptors |
Swedish | Alfa-1-adrenerga receptorer |
Finnish | Alfa-1-adrenergiset reseptorit |
Russian | ADRENERGICHESKIE AL'FA-1 RETSEPTORY, RETSEPTORY ADRENERGICHESKIE AL'FA-1, RETSEPTORY AL'FA-1 ADRENERGICHESKIE, AL'FA-1 ADRENERGICHESKIE RETSEPTORY, АДРЕНЕРГИЧЕСКИЕ АЛЬФА-1 РЕЦЕПТОРЫ, АЛЬФА-1 АДРЕНЕРГИЧЕСКИЕ РЕЦЕПТОРЫ, РЕЦЕПТОРЫ АДРЕНЕРГИЧЕСКИЕ АЛЬФА-1, РЕЦЕПТОРЫ АЛЬФА-1 АДРЕНЕРГИЧЕСКИЕ |
Italian | Recettore alfa-1 adrenergico, Recettori alfa-1 adrenergici |
German | REZEPTOREN ALPHA 1 ADRENERGE, ALPHA ADRENERGE REZEPTOREN 01, ADRENERGE REZEPTOREN ALPHA 01, Adrenerge Alpha-1-Rezeptoren, Alpha-1-adrenerge Rezeptoren, Rezeptoren, Alpha-1-adrenerge, Rezeptoren, adrenerge, Alpha-1- |
French | Récepteurs alpha-1 adrénergiques |
Czech | receptory adrenergní alfa-1, alfa-1-adrenergní receptory, alfa-1-adrenoreceptory |
Spanish | Receptores Adrenérgicos alfa-1, Receptores Adrenérgicos alfa 1, Receptor Adrenérgico alfa 1, Receptor alfa-1 Adrenérgico, Receptores alfa-1 Adrenérgicos |
Portuguese | Receptores Adrenérgicos alfa-1, Receptores alfa-1 Adrenérgicos, Receptores Adrenérgicos alfa 1, Receptor alfa-1 Adrenérgico, Receptor Adrenérgico alfa 1 |
Polish | Receptory adrenergiczne alfa 1 |
Japanese | アドレナリンアルファ1受容体, α1受容体, アドレナリンα1受容体, アルファ1アドレナリンレセプター, アルファ1アドレナリン受容体, 受容体-アドレナリン作用性アルファ1, アドレナリン作用性アルファ1受容体, アルファ1受容体, 受容体-アドレナリンα1 |
Ontology: Receptors, Adrenergic, alpha-2 (C0001639)
Definition (MSH) | A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release. |
Concepts | Receptor (T192) , Amino Acid, Peptide, or Protein (T116) |
MSH | D018341 |
English | Adrenergic Receptor, alpha-2, Adrenergic Receptors, alpha-2, alpha 2 Adrenergic Receptors, alpha-2 Adrenergic Receptor, alpha-2 Adrenergic Receptors, Receptor, alpha-2 Adrenergic, Receptors, alpha-2 Adrenergic, Receptor, Adrenergic, alpha-2, Adrenergic alpha-2 Receptors, Receptors, Adrenergic, alpha-2, Adrenergic Receptor, alpha 2, Receptors, Adrenergic alpha-2, Receptors, alpha 2 Adrenergic, alpha-2 Receptors, Adrenergic, ALPHA 2 ADREN RECEPT, ALPHA ADRENERGIC RECEPTORS 02, RECEPT ADREN ALPHA 2, RECEPT ALPHA 2 ADREN, ADREN ALPHA 2 RECEPT, RECEPTORS ALPHA 2 ADRENERGIC, ADRENERGIC RECEPTORS ALPHA 02, Receptors, Adrenergic, alpha-2 [Chemical/Ingredient], alpha-2-adrenergic receptors, alpha-2-AR, Adrenergic alpha 2 Receptors |
Swedish | Alfa-2-adrenerga receptorer |
Finnish | Alfa-2-adrenergiset reseptorit |
Russian | RETSEPTORY ADRENERGICHESKIE AL'FA-2, ADRENERGICHESKIE AL'FA-2 RETSEPTORY, AL'FA-2 ADRENERGICHESKIE RETSEPTORY, RETSEPTORY AL'FA-2 ADRENERGICHESKIE, АДРЕНЕРГИЧЕСКИЕ АЛЬФА-2 РЕЦЕПТОРЫ, АЛЬФА-2 АДРЕНЕРГИЧЕСКИЕ РЕЦЕПТОРЫ, РЕЦЕПТОРЫ АДРЕНЕРГИЧЕСКИЕ АЛЬФА-2, РЕЦЕПТОРЫ АЛЬФА-2 АДРЕНЕРГИЧЕСКИЕ |
German | ALPHA ADRENERGE REZEPTOREN 02, REZEPTOREN ALPHA 2 ADRENERGE, ADRENERGE REZEPTOREN ALPHA 02, Adrenerge Alpha-2-Rezeptoren, Alpha-2-adrenerge Rezeptoren, Rezeptoren, Alpha-2-adrenerge, Rezeptoren, adrenerge, Alpha-2- |
Italian | Recettore alfa-2 adrenergico, Recettori alfa-2 adrenergici |
French | Récepteurs alpha-2 adrénergiques |
Czech | alfa-2-adrenergní receptory, receptory adrenergní alfa-2, alfa-2-adrenoreceptory |
Spanish | Receptores Adrenérgicos alfa-2, Receptores Adrenérgicos alfa 2, Receptores alfa-2 Adrenérgicos |
Portuguese | Receptores Adrenérgicos alfa-2, Receptores Adrenérgicos alfa 2, Receptores alfa-2 Adrenérgicos |
Polish | Receptory adrenergiczne alfa 2 |
Japanese | α2受容体, アドレナリンアルファ2受容体, アドレナリンα2受容体, アルファ2アドレナリンレセプター, アルファ2アドレナリン受容体, 受容体-アドレナリン作用性アルファ2, アドレナリン作用性アルファ2受容体, アルファ2受容体, 受容体-アドレナリンα2 |
Ontology: Adrenergic alpha-Agonists (C0001640)
Definition (NCI) | Natural or synthetic Alpha-adrenergic Agonists selectively bind to and activate alpha adrenergic receptors of the sympathetic nervous system, mimicking the actions of natural sympathomimetic neurotransmitters (norepinephrine and related substances). Alpha-adrenergic Agonists can initiate physiological responses such as vasoconstriction, pupil dilation, and contraction of pilomotor muscles. (NCI04) |
Definition (MSH) | Drugs that selectively bind to and activate alpha adrenergic receptors. |
Concepts | Pharmacologic Substance (T121) |
MSH | D000316 |
SnomedCT | 349917000, 372622007 |
English | Adrenergic alpha Agonist, Adrenergic alpha Agonists, Adrenergic alpha Receptor Agonist, Adrenergic alpha Receptor Agonists, Adrenergic alpha-Agonist, Adrenergic alpha-Receptor Agonist, Adrenergic alpha-Receptor Agonists, Agonist, Adrenergic alpha-Receptor, Agonist, alpha-Adrenergic, Agonist, alpha-Adrenergic Receptor, Agonists, Adrenergic alpha-Receptor, Agonists, alpha-Adrenergic, Agonists, alpha-Adrenergic Receptor, Receptor Agonist, alpha-Adrenergic, Receptor Agonists, Adrenergic alpha, Receptor Agonists, alpha Adrenergic, Receptor Agonists, alpha-Adrenergic, alpha Adrenergic Agonist, alpha Adrenergic Agonists, alpha Adrenergic Receptor Agonist, alpha Adrenergic Receptor Agonists, alpha-Adrenergic Agonist, alpha-Adrenergic Agonists, alpha-Adrenergic Receptor Agonist, alpha-Adrenergic Receptor Agonists, alpha-Agonist, Adrenergic, alpha-Agonists, Adrenergic, alpha-Receptor Agonist, Adrenergic, alpha-Receptor Agonists, Adrenergic, Alpha-Adrenergic Agonist, ADREN ALPHA RECEPT AG, ADREN ALPHA AGON, ADRENERGIC RECEPTOR AGONISTS ALPHA, RECEPT AGON ALPHA ADREN, ADRENERGIC AGONISTS ALPHA, ALPHA ADREN RECEPT AG, ADREN ALPHA AG, ALPHA ADREN RECEPT AGON, ADREN ALPHA RECEPT AGON, RECEPT AGON ADREN ALPHA, ALPHA ADREN AG, ALPHA ADREN AGON, adrenergic alpha receptor agonists, Adrenergic alpha-Agonists, alpha-adrenergic receptor agonists, alpha adrenergic agonists, alpha-adrenergic agonists, alpha-adrenergic agonist, Alpha-adrenoceptor agonist, Alpha-adrenoceptor agonist (product), Alpha-adrenoceptor agonist (substance), Alpha-adrenergic Agonists |
Swedish | Adrenerga alfastimulerare |
Czech | receptory adrenergní alfa - agonisté |
Finnish | Alfa-agonistit |
Russian | AL'FA-ADRENORETSEPTOROV AGONISTY, ADRENERGICHESKIKH AL'FA-RETSEPTOROV AGONISTY, ADRENORETSEPTOROV-AL'FA AGONISTY, ADRENERGICHESKIE AL'FA-AGONISTY, АДРЕНЕРГИЧЕСКИЕ АЛЬФА-АГОНИСТЫ, АДРЕНЕРГИЧЕСКИХ АЛЬФА-РЕЦЕПТОРОВ АГОНИСТЫ, АДРЕНОРЕЦЕПТОРОВ-АЛЬФА АГОНИСТЫ, АЛЬФА-АДРЕНОРЕЦЕПТОРОВ АГОНИСТЫ |
Japanese | α-作動剤, α-作動薬, α-作用薬, α-刺激薬, アドレナリンアルファアゴニスト, アドレナリン作用性アルファ受容体作用薬, アルファアドレナリン作用性受容体作用薬, アドレナリン作用性アルファ受容体作用剤, アドレナリン作用性アルファ受容体作用物質, アドレナリン作用性アルファ受容器作用物質 |
Italian | Recettore adrenergico alfa-agonista, Alfa-agonista adrenergico, Recettori adrenergici alfa-agonisti, Alfa-agonisti adrenergici |
German | ADRENERGE AGONISTEN ALPHA, Adrenerge Alpha-Agonisten, Alpha-Adrenomimetika, Alpha-adrenerge Rezeptoragonisten |
Polish | Agoniści adrenergiczni alfa, Alfa-mimetyki, Agoniści receptora adrenergicznego alfa |
French | Agonistes des adrénorécepteurs alpha, Alpha-stimulants, Sympathomimétiques alpha, Agoniste alpha-adrénergique, Agonistes alpha-adrénergiques, Agonistes des récepteurs alpha-adrénergiques, Alpha-mimétiques |
Portuguese | Agonistas dos Receptores Adrenérgicos alfa, Agonistas Adrenérgicos alfa, Agonistas alfa-Adrenérgicos, alfa-Agonistas Adrenérgicos, Agonistas dos Receptores alfa-Adrenérgicos, Agonistas dos alfa-Receptores Adrenérgicos |
Spanish | Agonistas Adrenérgicos alfa, Agonistas de los Receptores Adrenérgicos alfa, Agonistas alfa-Adrenérgicos, Agonistas de los Receptores alfa-Adrenérgicos, alfa-Agonistas Adrenérgicos, agonista adrenérgico alfa, agonista alfa adrenérgico (producto), agonista alfa adrenérgico (sustancia), agonista alfa adrenérgico, agonista alfa-adrenérgico (sustancia), agonista alfa-adrenérgico |
Ontology: alpha-adrenergic receptor (C0034784)
Definition (MSH) | One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation. |
Definition (NCI) | Expressed by Alpha Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. |
Definition (CSP) | alpha-1 is coupled to phospholipase C, such that stimulation results in production of second messengers DAG and in inositol phosphates; alpha-2 is coupled to adenylate cyclase such that stimulation lowers cyclic AMP. |
Concepts | Receptor (T192) , Amino Acid, Peptide, or Protein (T116) |
MSH | D011942 |
SnomedCT | 42938005 |
English | Adrenergic alpha Receptors, alpha adrenergic receptor, alpha Adrenergic Receptors, Receptors, Adrenergic, alpha, Receptors, alpha Adrenergic, Receptor, Adrenergic, alpha, Adrenergic alpha-Receptors, Receptors, alpha-Adrenergic, alpha-Adrenergic Receptors, alpha-Receptors, Adrenergic, RECEPT ALPHA ADREN, RECEPT ADREN ALPHA, ADREN ALPHA RECEPT, ALPHA ADREN RECEPT, ADRENERGIC RECEPTORS ALPHA, alpha-Adrenergic receptor site, Alpha adrenergic receptor, Receptors, Adrenergic, alpha [Chemical/Ingredient], alpha-adrenergic receptor, alpha adrenergic receptors, Alpha adrenoceptors, alpha-Adrenergic receptor (substance), alpha-Adrenergic receptor, Alpha Adrenergic Receptor |
Swedish | Alfaadrenerga receptorer |
Finnish | Alfa-adrenergiset reseptorit |
Russian | RETSEPTORY ADRENERGICHESKIE AL'FA, AL'FA-ADRENERGICHESKIE RETSEPTORY, ADRENERGICHESKIE AL'FA-RETSEPTORY, AL'FA-ADRENORETSEPTORY, RETSEPTORY AL'FA-ADRENERGICHESKIE, АДРЕНЕРГИЧЕСКИЕ АЛЬФА-РЕЦЕПТОРЫ, АЛЬФА-АДРЕНЕРГИЧЕСКИЕ РЕЦЕПТОРЫ, АЛЬФА-АДРЕНОРЕЦЕПТОРЫ, РЕЦЕПТОРЫ АДРЕНЕРГИЧЕСКИЕ АЛЬФА, РЕЦЕПТОРЫ АЛЬФА-АДРЕНЕРГИЧЕСКИЕ |
Italian | Recettore alfa adrenergico, Recettori alfa adrenergici |
German | ADRENERGE REZEPTOREN ALPHA, Adrenerge Alpha-Rezeptoren, Alpha-Adrenerge Rezeptoren, Rezeptoren, Alpha-adrenerge, Rezeptoren, adrenerge, Alpha- |
Croatian | RECEPTORI, ADRENERGIČKI, ALFA |
French | Récepteurs alpha-adrénergiques |
Czech | alfa-adrenoreceptory, alfa-adrenergní receptory, receptory adrenergní alfa |
Polish | Receptory adrenergiczne alfa |
Japanese | アドレナリンアルファ受容体, α受容体, αレセプター, アドレナリンα受容体, アドレナリン作用性アルファ受容体, アルファアドレナリンレセプター, アルファアドレナリン受容体, アルファ受容体, 受容体-アドレナリン作用性アルファ, 受容体-アドレナリンα |
Portuguese | Receptores alfa Adrenérgicos, Receptores alfa-Adrenérgicos, Receptores Adrenérgicos alfa |
Spanish | Receptores alfa Adrenérgicos, Receptores Adrenérgicos alfa, Receptores alfa-Adrenérgicos, receptor alfa - adrenérgico (sustancia), receptor alfa - adrenérgico |