II. Indications
-
Hypertensive Crisis of Pheochromocytoma
- Not indicated in routine benign Hypertension
III. Mechanism
- Synthetic dibenzamine Alpha Adrenergic Antagonist at post-synaptic Adrenergic Receptors (alpha-1 and alpha-2)
- Binding results in non-selective, irreversible alkylation of the Alpha Adrenergic Receptor
- Causes Smooth Muscle relaxation, blocking Vasoconstriction and vasospasm
IV. Dosing: Adults
- Start 10 mg orally twice daily
- Titrate to typical dose 20 to 40 mg orally twice daily
- Maximum total daily dose: 120 mg/day
V. Dosing: Children (Not FDA approved)
- Start 0.2 mg/kg/day (up to 20 mg/day or 10 mg/dose) divided twice daily orally
- May titrate 0.4 to 1.2 mg/kg/day up to 20 to 40 mg orally twice daily
VI. Adverse Effects
- Symptomatic Hypotension
- Observe after dosing
- Reflex Tachycardia
- Possibly carcinogenic
VII. Safety
- Pregnancy Category C
- Unknown Safety in Lactation
VIII. Resources
- Phenoxybenzamine Capsule (DailyMed)
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Related Studies
Definition (NCI) | A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
Definition (MSH) | An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010643 |
SnomedCT | 372838003, 74771007 |
English | Phenoxybenzamine, phenoxybenzamine, Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine, Phenoxybenzamine [Chemical/Ingredient], PHENOXYBENZAMINE, Phenoxybenzamine (product), Phenoxybenzamine (substance) |
Swedish | Fenoxibensamin |
Czech | fenoxybenzamin |
Finnish | Fenoksibentsamiini |
Russian | FENOKSIBENZAMIN, BENSILIT, БЕНСИЛИТ, ФЕНОКСИБЕНЗАМИН |
Croatian | FENOKSIBENZAMIN |
Polish | Fenoksybenzamina, Dwubenzylina |
Japanese | 塩酸フェノキシベンザミン, フェノキシベンザミン塩酸塩, フェノキシベンザミン, ジベンジリン, ジベニリン |
Spanish | fenoxibenzamina (producto), fenoxibenzamina (sustancia), fenoxibenzamina, Fenoxibenzamina |
French | Phénoxybenzamine |
German | Bensylytum, Phenoxybenzamin |
Italian | Fenossibenzamina |
Portuguese | Fenoxibenzamina |
Ontology: Dibenzyline (C0701367)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D010643 |
English | Dibenzylin, dibenzyline, Wellspring Brand of Phenoxybenzamine Hydrochloride, Dibenzyline |