II. Indications

  1. Hypertensive Crisis of Pheochromocytoma
    1. Not indicated in routine benign Hypertension

III. Mechanism

  1. Synthetic dibenzamine Alpha Adrenergic Antagonist at post-synaptic Adrenergic Receptors (alpha-1 and alpha-2)
  2. Binding results in non-selective, irreversible alkylation of the Alpha Adrenergic Receptor
  3. Causes Smooth Muscle relaxation, blocking Vasoconstriction and vasospasm

IV. Dosing: Adults

  1. Start 10 mg orally twice daily
  2. Titrate to typical dose 20 to 40 mg orally twice daily
  3. Maximum total daily dose: 120 mg/day

V. Dosing: Children (Not FDA approved)

  1. Start 0.2 mg/kg/day (up to 20 mg/day or 10 mg/dose) divided twice daily orally
  2. May titrate 0.4 to 1.2 mg/kg/day up to 20 to 40 mg orally twice daily

VI. Adverse Effects

  1. Symptomatic Hypotension
    1. Observe after dosing
  2. Reflex Tachycardia
  3. Possibly carcinogenic

VII. Safety

  1. Pregnancy Category C
  2. Unknown Safety in Lactation

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Ontology: Phenoxybenzamine (C0031441)

Definition (NCI) A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
Definition (MSH) An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D010643
SnomedCT 372838003, 74771007
English Phenoxybenzamine, phenoxybenzamine, Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine, Phenoxybenzamine [Chemical/Ingredient], PHENOXYBENZAMINE, Phenoxybenzamine (product), Phenoxybenzamine (substance)
Swedish Fenoxibensamin
Czech fenoxybenzamin
Finnish Fenoksibentsamiini
Russian FENOKSIBENZAMIN, BENSILIT, БЕНСИЛИТ, ФЕНОКСИБЕНЗАМИН
Croatian FENOKSIBENZAMIN
Polish Fenoksybenzamina, Dwubenzylina
Japanese 塩酸フェノキシベンザミン, フェノキシベンザミン塩酸塩, フェノキシベンザミン, ジベンジリン, ジベニリン
Spanish fenoxibenzamina (producto), fenoxibenzamina (sustancia), fenoxibenzamina, Fenoxibenzamina
French Phénoxybenzamine
German Bensylytum, Phenoxybenzamin
Italian Fenossibenzamina
Portuguese Fenoxibenzamina

Ontology: Dibenzyline (C0701367)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D010643
English Dibenzylin, dibenzyline, Wellspring Brand of Phenoxybenzamine Hydrochloride, Dibenzyline