II. Indications
III. Contraindications
- See Fibric Acid Derivative
- Avoid in Serum Creatinine >=2 mg/dl
IV. Dosing
- Take 600 mg orally twice daily at 30 minutes before meals
V. Efficacy
- See Fibric Acid Derivative
- No Fibrate has been shown to reduce all cause mortality
- Gemfibrozil is the only Fibrate shown to decrease cardiovascular events
- NNT to prevent one coronary event: 46-125
VI. Adverse Effects
VII. Safety
- Pregnancy Category C
- Unknown safety in Lactation
VIII. Drug Interactions
- See Fibric Acid Derivative
- Avoid with specific other medications
- Statins (esp. Simvastatin)
- Dasabuvir
- Repaglinide
- Increases levels of other medications
- CYP2C8 Substrates (e.g. Montelukast, Paclitaxel, Pioglitazone)
- OATP1B1 Substrates (e.g. Ezetimibe, Glyburide, Olmesartan, Rifampin)
- Warfarin
IX. Resources
Images: Related links to external sites (from Bing)
Related Studies
| gemfibrozil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| GEMFIBROZIL 600 MG TABLET | Generic | $0.10 each |