III. Contraindications

  1. See Fibric Acid Derivative
  2. Avoid in Serum Creatinine >=2 mg/dl

IV. Dosing

  1. Take 600 mg orally twice daily at 30 minutes before meals

V. Efficacy

  1. See Fibric Acid Derivative
  2. No Fibrate has been shown to reduce all cause mortality
  3. Gemfibrozil is the only Fibrate shown to decrease cardiovascular events
    1. NNT to prevent one coronary event: 46-125

VI. Adverse Effects

VII. Safety

  1. Pregnancy Category C
  2. Unknown safety in Lactation

VIII. Drug Interactions

  1. See Fibric Acid Derivative
  2. Avoid with specific other medications
    1. Statins (esp. Simvastatin)
    2. Dasabuvir
    3. Repaglinide
  3. Increases levels of other medications
    1. CYP2C8 Substrates (e.g. Montelukast, paclitaxel, Pioglitazone)
    2. OATP1B1 Substrates (e.g. Ezetimibe, Glyburide, Olmesartan, Rifampin)
    3. Warfarin

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

gemfibrozil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
GEMFIBROZIL 600 MG TABLET Generic $0.10 each