II. Mechanism

  1. Selective Beta Blocker

IV. Pharmacokinetics

  1. Half-Life: 9 minutes
    1. Rapidly metabolized by erythrocyte esterase
  2. Duration of action: 15-20 minutes

V. Dosing: Intravenous

  1. Preparation: 2.5 g (10 ml ampule) in 250 ml (10 mg/ml)
  2. Load: 250-500 mcg/kg over 1 min (70 kg: 35 mg, 3.5 ml)
  3. Infusion:
    1. Start 25-50 mcg/kg/min IV (70 kg: 10 ml/h provides 25 mcg/kg/min)
    2. Titrate up 25-50 mcg/kg every 5 to 10 min to max 300 mcg/kg/min

VI. References

  1. Hamilton (2010) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Pevtsov (2022) Esmolol, StatPearls, Treasure Island, FL (accessed 12/25/2022)
    1. https://www.ncbi.nlm.nih.gov/books/NBK518965/

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