II. Indications
III. Dosing: Adults
- Background
- Tablets are extended release
- Swallow whole and do not crush or chew
- Take on an empty Stomach or with a light meal
- Start 2.5 to 5 mg orally daily
- Target 5 to 10 mg orally daily
- Maximum 10 mg/day
IV. Mechanism
- See Dihydropyridine Calcium Channel Blocker
- Peripheral Vasodilation
- Increases myocardial contractility and Cardiac Output
V. Adverse Effects
- See Dihydropyridine Calcium Channel Blocker
- Appears safe in Congestive Heart Failure with Reduced Ejection Fraction
- Peripheral Edema
- Flushing
- Headache
- Dizziness
VI. Safety
- Pregnancy Category C
- Unknown Safety in Lactation
VII. Drug Interactions
- Felodipine Levels lowered by strong CYP3A4 Inhibitors (Ketoconazole, Itraconazole, Erythromycin)
- Digoxin levels are increased by Felodipine
VIII. Pharmacokinetics
- Slow onset of action (2 to 5 hours)
IX. Resources
- Felodipine Extended Release Tablet (DailyMed)
X. References
- (2022) Presc Lett, Resource #381108, Comparison of Calcium Channel Blockers
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 70-1
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
felodipine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
FELODIPINE ER 10 MG TABLET | Generic | $0.21 each |
FELODIPINE ER 2.5 MG TABLET | Generic | $0.18 each |
FELODIPINE ER 5 MG TABLET | Generic | $0.21 each |
Ontology: Felodipine (C0015772)
Definition (NCI) | A dihydropyridine calcium channel blocking agent. Felodipine inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
Definition (MSH) | A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D015736 |
SnomedCT | 108535009, 386863007 |
English | Felodipine, 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester, felodipine (medication), felodipine, FELODIPINE, Felodipine ER, Felodipine [Chemical/Ingredient], Felodipine (product), Felodipine (substance) |
Swedish | Felodipin |
Czech | felodipin |
Finnish | Felodipiini |
Russian | FELODIPIN, ФЕЛОДИПИН |
Japanese | フェロジピン |
Spanish | felodipina (producto), felodipino, felodipino (sustancia), felodipina, felodipino (producto), felodipina (sustancia), Felodipino |
Polish | Felodypina |
French | Félodipine |
German | Felodipin |
Italian | Felodipina |
Portuguese | Felodipino |
Ontology: Plendil (C0700021)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D015736 |
English | plendil, Plendil, Astra Brand of Felodipine, AstraZeneca Brand of Felodipine, Flodil, Modip, Promed Brand of Felodipine |