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Definition (MSH)
|
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
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|
Definition (CHV)
|
a hypertension treatment drug
|
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Definition (NCI)
|
An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.
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Definition (NCI_NCI-GLOSS)
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The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist.
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Definition (CSP)
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alpha-2 adrenergic agonist that crosses the blood-brain barrier; acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate; also acts peripherally.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| MSH |
D003000
|
| SnomedCT |
22139009, 372805007, 62782004 |
| LNC |
LP32548-7, LP14987-9, MTHU002290 |
| English |
Clofenil, Clonidine, Klofenil, 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, clonidine, clonidine (medication), Clonidine [Chemical/Ingredient], CLONIDINE, cloNIDine, Clonidine (product), Clonidine (substance) |
| Swedish |
Klonidin
|
| Finnish |
Klonidiini
|
| Russian |
KHLOFAZOLIN, GEMITON, KATAPRESAN, KLOFELIN, KLONIDIN, ГЕМИТОН, КАТАПРЕСАН, КЛОНИДИН, КЛОФЕЛИН, ХЛОФАЗОЛИН |
| Japanese |
クロニジン塩酸塩, カタプレス, クロニジン, 塩酸クロニジン |
| Croatian |
KLONIDIN
|
| Polish |
Klonidyna
|
| Czech |
clonidin, klonidin |
| Spanish |
clonidina (producto), clonidina (sustancia), clonidina, Clonidina |
| French |
Clonidine
|
| German |
Clonidin
|
| Italian |
Clonidina
|
| Portuguese |
Clonidina
|
